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Trichothecene MycotoxinAka: T2 toxin, Trichothecene

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  1. See Also
    1. Mycotoxin
  2. Pathophysiology
    1. Agent
      1. Trichothecene Mycotoxins
        1. Produced by filamentous fungi (molds)
      2. Inactivation
        1. Extremely stable in heat and UV light
        2. Destruction requires heating 1500 F for 30 minutes
        3. Brief exposure to sodium Hypochlorite inactivates
    2. Transmission
      1. Used as aerosolized Biological Weapon
        1. Laos, Kampuchea, Afghanistan in late 1970's
      2. Aerosol: "yellow rain" drops of yellow fluid
  3. Symptoms and signs
    1. Skin
      1. Local pain
      2. Pruritus
      3. Skin redness
      4. Vesicles
      5. Skin necrosis and sloughing
    2. Respiratory
      1. Nose and throat pain
      2. Nasal discharge
      3. Itching and sneezing
      4. Cough
      5. Dyspnea
      6. Wheezing
      7. Chest Pain
      8. Hemoptysis
    3. Severe systemic
      1. Prostration
      2. Weakness
      3. Ataxia
      4. Collapse
      5. Shock
      6. Death
  4. Differential Diagnosis
    1. Mustard agents
    2. Staphylococcal Enterotoxin B
    3. Ricin
  5. Management
    1. Activated Charcoal for ingestion
  6. Prevention
    1. No vaccine or antitoxin available
    2. Decontamination

T-2 Toxin (C0039185)

Definition (MSH)A potent mycotoxin produced in feedstuffs by several species of the genus FUSARIUM. It elicits a severe inflammatory reaction in animals and has teratogenic effects.
Definition (CSP)potent mycotoxin produced in feedstuffs by some Fusarium species.
ConceptsOrganic Chemical (T109) , Hazardous or Poisonous Substance (T131)
MSHD013605
EnglishFusariotoxin, Fusaritoxin, Mycotoxin T2, T 2 Toxin, T AA TOXIN 02, T-2 fungal toxin, T-2 Toxin, T2 Toxin
Spanishmicotoxina T-2, toxina fungica T-2, toxina T-2
Parent ConceptsMycotoxins (C0026955), Sesquiterpenes (C0036847), Trichothecenes (C0040952)
SourcesCSP, MSH, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)


Trichothecenes (C0040952)

Definition (MSH)Usually 12,13-epoxytrichothecenes, produced by Fusaria, Stachybotrys, Trichoderma and other fungi, and some higher plants. They may contaminate food or feed grains, induce emesis and hemorrhage in lungs and brain, and damage bone marrow due to protein and DNA synthesis inhibition.
ConceptsOrganic Chemical (T109) , Biologically Active Substance (T123) , Hazardous or Poisonous Substance (T131)
MSHD014255
EnglishFusarium toxins, Trichothecene, Trichothecenes
Spanishtoxina de fusario, tricotecenos
Parent ConceptsMycotoxins (C0026955), Sesquiterpenes (C0036847), Macrocyclic Compounds (C1449665)
SourcesLCH, MSH, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)



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