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Burning Mouth Syndrome

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  1. Epidemiology
    1. Patients are generally older
    2. More common in women by ratio of 7:1
    3. Prevalence: 1 million in U.S. affected
  2. Pathophysiology
    1. No clear etiology identified
    2. Postulated etiologies
      1. Nutritional Deficiency
        1. B Vitamin Deficiency
        2. Iron Deficiency Anemia
      2. Major Depresion
      3. Increased Taste Sensation
      4. Xerostomia
      5. Menopause (90% of women are postmenopausal)
      6. Trigeminal Nerve (CN V) Neuropathy
      7. Candidiasis
      8. Dentures
      9. Diabetes Mellitus
  3. Symptoms
    1. Characteristics of pain
      1. Burning pain affecting oropharynx
      2. Pain may be severe toothache-like pain
    2. Timing
      1. Onset in mid-morning
      2. Progression over course of day
      3. Peaks in late afternoon
      4. Subsides at night (may interfere with going to sleep)
    3. Multiple pain sites often affected
      1. Anterior two-thirds of Tongue
      2. Oral Mucosa (especially anterior Hard Palate)
      3. Lower lip mucosa
    4. Palliative
      1. Pain may be relieved with eating
    5. Provocative
      1. Worse with emotion, speech
    6. Associated symptoms
      1. Dry Mouth (Xerostomia)
      2. Taste disturbance (bitter or Metallic Taste)
  4. Signs
    1. No lesions present
  5. Differential Diagnosis
    1. See Tongue Pain
  6. Labs
    1. Complete Blood Count
    2. Serum Iron or Ferritin
    3. Serum Vitamin B12
    4. Zinc
    5. KOH and Fungal Culture
    6. Serum Glucose or Hemoglobin A1C
  7. Associated Conditions
    1. Mood disturbance including Major Depression
  8. Course
    1. Spontaneous onset with persistence for years
  9. Management
    1. Treat potential causes of differential diagnosis
      1. Antifungal agent for Oral Candidiasis (Thrush)
      2. Estrogen Replacement for Menopause
      3. B Vitamin Supplementation for B Vitamin Deficiency
      4. Increase Saliva in Xerostomia
    2. Neuropathic pain medications
      1. Amitriptyline (Elavil) at bedtime
      2. Clonazepam (Klonopin) at bedtime
      3. Gabapentin (Neurontin) at bedtime
      4. Capsaicin
        1. Start with hot pepper diluted 1:2 with water
        2. Rinse mouth with 1 teaspoon
        3. May decrease dilution to 1:1 as tolerated
  10. References
    1. Muzyka (1999) Cutis 64(1):29
    2. Grushka (2002) Am Fam Physician 65(4):615

Burning Mouth Syndrome (C0006430)

Definition (MSH)A group of painful oral symptoms associated with a burning or similar sensation. There is usually a significant organic component with a degree of functional overlay; it is not limited to the psychophysiologic group of disorders.
Definition (NCI)A condition characterized by a burning or tingling sensation on the lips, tongue, or entire mouth.
ConceptsDisease or Syndrome (T047)
EnglishBurning Mouth Syndrome, Burning Mouth Syndromes, Orodynia, Stomatopyrosis
Spanishsíndrome de la boca quemante, sindrome de la boca quemante
CreditsDerived from the NIH UMLS (Unified Medical Language System)



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