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CapsaicinAka: Zostrix
- Indications
- Mechanism
- Derived from jalapeno peppers
- Depletes Substance P from pain fibers
- Requires frequent and repeat applications for affect
- Inconsistent use not effective
- Dose
- Apply capsaicin cream to affected area 3-5 times daily
- Adverse effects
- Burning sensation on initial application
- Increased pain for up to first week of application
- Precautions
- Wash hands thoroughly after capsaicin application
Capsaicin (C0006931) | |
|---|---|
| Definition (MSH) | An alkylamide found in CAPSICUM that acts at TRPV CATION CHANNELS. |
| Definition (CSP) | N-(4-hydroxy-3-methoxyphenylmethyl) -8-methyl-6-nonenamide; chili pepper extract and neuropeptide releasing agent selective for primary sensory peripheral neurons, used to experimentally manipulate substance P and other tachykinins, and as an analgesic for Herpes zoster infection. |
| Definition (NCI) | A component of certain plants, including cayenne and red pepper, used topically for peripheral nerve pain. Also being studied for controlling mucositis pain after chemotherapy and radiation therapy. |
| Definition (NCI) | A chili pepper extract with analgesic properties. Capsaicin is a neuropeptide releasing agent selective for primary sensory peripheral neurons. Used topically, capsaicin aids in controlling peripheral nerve pain. This agent has been used experimentally to manipulate substance P and other tachykinins. In addition, capsaicin may be useful in controlling chemotherapy- and radiotherapy-induced mucositis. |
| Concepts | Lipid (T119) , Pharmacologic Substance (T121) |
| MSH | D002211 |
| English | 8 Methyl N Vanillyl 6 Nonenamide, 8-Methyl-N-Vanillyl-6-Nonenamide, Capsaicin, CAPSAICIN PREPARATION, Capsaicine |
| Spanish | capsaicina |
| Parent Concepts | Solanaceous Alkaloids (C0037600), neuropharmacologic agent (C0597058), phenylamide (C0597215), Catechols (C0007413), Fatty Acids, Monounsaturated (C0015687), Polyunsaturated Alkamides (C1720954), Analgesics, Non-Narcotic (C0242937), [DE650] ANALGESICS, TOPICAL (C0973527), Counterirritants (C0010215), Phytotoxin (C0032086), Drug allergen (C1320237) |
| Sources | AOD, CSP, LCH, MSH, NCI, NDFRT, PDQ, RXNORM, SCTSPA, SNOMEDCT, VANDF Derived from the NIH UMLS (Unified Medical Language System) |
Zostrix (C0308191) | |
|---|---|
| Concepts | Organic Chemical (T109) , Pharmacologic Substance (T121) |
| MSH | D002211 |
| English | Capsaicin Link Brand, Capsaicin Medicis Brand, Link Brand of Capsaicin, Medicis Brand of Capsaicin, Zostrix |
| Sources | MSH, MTH, RXNORM Derived from the NIH UMLS (Unified Medical Language System) |
