Definition
1. Allergic constellation centered around Aspirin allergy
Associated Conditions
1. Aspirin-induced Asthma
2. Rhinorrhea
3. Nasal Polyps
4. Chronic Sinusitis
5. Conjunctival edema
Course
1. Onset as perennial Vasomotor Rhinitis
2. Develops into hyperplastic Rhinosinusitis, Nasal Polyps
Causes
1. Aspirin
2. Cross-reactivity with NSAIDs
  1. Indomethacin
  2. Naproxen
  3. Ibuprofen
  4. Fenoprofen
  5. Mefenamic acid
  6. Phenylbutazone
Management
1. Avoid Aspirin and causative NSAIDs above
2. Use safe alternative Analgesics instead
  1. Salsalate
  2. Acetaminophen
3. Treat Aspirin-induced Asthma
  1. Leukotriene modifiers (e.g. Sinulair)

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This page was written by Scott Moses, MD. This page was last revised before 5/10/08, prior to consistent tracking of revision date. This page was last published on 6/1/2008. Please send comments and questions to the editor. Contact information may be found on the page About the Family Practice Notebook. These pages are best viewed with Microsoft Internet Explorer 6.0.