II. Class

  1. NSAID in the propionic acid class

III. Pharmacokinetics

  1. Naproxen Sodium has faster action onset than Naproxen

IV. Dosing

  1. Naproxen (Naprosyn) 250-500 mg orally twice daily prn
  2. Naproxen Sodium (Anaprox, Aleve) 550 mg orally twice daily prn

V. Adverse Effects

  1. See NSAID Gastrointestinal Adverse Effects
  2. See NSAID Renal Adverse Effects
  3. Bleeding risk (inhibits platelet aggregation)
    1. Naprosyn increases risk almost as much as Aspirin

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Cost: Medications

Naproxen (on 6/18/2017 at Walmart.com)
Naproxen 375mg #60 tablets for $4.00 $0.07 each
Naproxen 375mg #180 tablets for $10.00 $0.06 each
Naproxen 500mg #60 tablets for $4.00 $0.07 each
Naproxen 500mg #180 tablets for $10.00 $0.06 each
naproxen (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
NAPROXEN 125 MG/5 ML SUSPEN Generic $0.74 per ml
NAPROXEN 250 MG TABLET Generic $0.04 each
NAPROXEN 375 MG TABLET Generic $0.06 each
NAPROXEN 500 MG TABLET Generic $0.06 each
NAPROXEN DR 375 MG TABLET Generic $0.14 each
NAPROXEN DR 500 MG TABLET Generic $0.20 each
NAPROXEN SOD CR 500 MG TABLET Generic $12.83 each
NAPROXEN SOD ER 500 MG TABLET Generic $12.83 each
NAPROXEN SODIUM 220 MG TABLET Generic OTC $0.06 each
NAPROXEN SODIUM 275 MG TAB Generic $1.12 each
NAPROXEN SODIUM 550 MG TAB Generic $1.28 each
NAPROXEN SODIUM DS 550 MG TAB Generic $1.28 each

Ontology: Naproxen (C0027396)

Definition (CHV) a drug that relieves pain, inflammation, and fever
Definition (NCI_NCI-GLOSS) A drug used to treat mild pain and the symptoms of arthritis and several other conditions. It is also being studied in the treatment of bone pain in patients with cancer. Naprosyn stops the body from making substances that cause pain and inflammation. It is a type of nonsteroidal anti-inflammatory drug (NSAID) and a type of cyclooxygenase inhibitor.
Definition (NCI) A propionic acid derivative and a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, antipyretic and analgesic activities. Naproxen inhibits the activity of the enzymes cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. The resulting decrease in prostaglandin synthesis is responsible for the therapeutic effects of naproxen. Naproxen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation.
Definition (MSH) An anti-inflammatory agent with analgesic and antipyretic properties. Both the acid and its sodium salt are used in the treatment of rheumatoid arthritis and other rheumatic or musculoskeletal disorders, dysmenorrhea, and acute gout.
Definition (CSP) 6-methoxy-alpha-methyl-2-naphthaleneacetic acid; nonsteroidal antiinflammatory drug (NSAID); acts by inhibiting cyclooxygenase and thus prostaglandin synthesis; tocolytic oxytocin antagonist.
Definition (PDQ) A propionic acid derivative and a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, antipyretic and analgesic activities. Naproxen inhibits the activity of the enzymes cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. The resulting decrease in prostaglandin synthesis is responsible for the therapeutic effects of naproxen. Naproxen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40222&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40222&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C680" NCI Thesaurus)
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D009288
SnomedCT 363614005, 11847009, 372588000
LNC LP16215-3, MTHU015374
English Methoxypropiocin, MNPA, Naproxen, 2-Naphthaleneacetic acid, 6-methoxy-alpha-methyl-, (S)-, d-2-(6-Methoxy-2-naphthyl)propionic Acid, 6-Methoxy-alpha-methyl-2-naphthaleneacetic Acid, naproxen, NAPROXEN, naproxen (medication), non-prescription naproxen, non-prescription naproxen (medication), Naproxen [Chemical/Ingredient], Naproxen product, Naproxen product (substance), Naproxen (product), Naproxen (substance)
Swedish Naproxen
Czech naproxen
Finnish Naprokseeni
Russian NAPROKSEN, НАПРОКСЕН
Japanese ナプロキセン
Spanish Naproxeno, Naproxen, naproxeno (producto), naproxeno (sustancia), naproxeno
Polish Naproksen
French Naproxène
German Naproxen
Italian Naproxene
Portuguese Naproxeno

Ontology: Anaprox (C0699095)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D009288
English anaprox, Anaprox

Ontology: Naprosyn (C0700017)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D009288
English naprosyn, naprosin, Naprosin, Naprosyn

Ontology: Aleve (C0718343)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D009288
English aleve, Aleve