II. Indications

III. Contraindications

  1. Do not use with live virus Vaccines

IV. Mechanism

  1. Monoclonal Antibody to the CD20 Antigen that depletes CD20 positive B Cells

V. Dosing

  1. Rheumatoid Arthritis: 1 gram IV every 2 weeks for 2 doses
    1. Administered with Methylprednisolone 100 mg
  2. Non-Hodgkin's Lymphoma or ANCA Vasculitis: 375 mg/m2 IV weekly for 4 doses

VI. Adverse Effects

  1. Severe infusion reactions (follows first infusion within 30-120 minutes)
  2. Tumor Lysis Syndrome
  3. Hepatitis B reactivation
  4. Renal Insufficiency

VII. Monitoring

  1. PPD before initiating therapy
  2. Complete Blood Count at initiation of therapy and then periodically after

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