Goodpasture's Syndrome

Aka: Goodpasture's Syndrome, Goodpasture Syndrome

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II. Pathophysiology

  1. Antibody to renal and alveolar basement membrane
    1. Intraalveolar Hemorrhage
    2. Glomerulonephritis

III. Symptoms and Signs

  1. Pulmonary
    1. Hemoptysis
    2. Cough
    3. Exertional Dyspnea
    4. Rales and rhonchi on Lung Exam
  2. Renal
    1. Glomerulonephritis

IV. Labs

  1. Basement Membrane Antibody (anti-GBM) present
  2. Complete Blood Count
    1. Normochromic Anemia
  3. Gastric aspirate or Bloody Sputum exam
    1. Siderophages
  4. Urinalysis
    1. Consistent with Glomerulonephritis

V. Imaging: Chest XRay

  1. Bilateral perihilar patchy infiltrates

VI. Diagnosis

  1. Renal Biopsy
    1. Linear Immunofluorescence
  2. Lung Biopsy
    1. Linear IgG

VII. Course

  1. Rapidly Progressive Glomerulonephritis is typical
  2. Renal Failure usually ensues

VIII. Management

  1. Plasma exchange
  2. Glucocorticoids IV for severe lung Hemorrhage

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