II. Indications

  1. Schizophrenia
  2. Bipolar Disorder (Type 1)
  3. Acute Mania or mixed disorder

III. Mechanism

  1. Atypical Antipsychotic
  2. Dopamine Partial Agonist at D2 and D3 receptors

IV. Dosing: Schizophrenia, Bipolar 1 Disorder, Mania

  1. Start 1.5 mg orally daily
  2. May increase to 3 mg orally daily after the first day (after 2 weeks in Bipolar Depression)
  3. Maximum: 6 mg/day

V. Drug Interactions

  1. Cariprazine is metabolized by CYP3A4
  2. Reduce Cariprazine dose when taking strong CYP3A4 Inhibitors

VI. Safety

  1. Unknown safety in pregnancy and Lactation

VII. Adverse Effects

IX. References

  1. (2016) Med Lett Drugs Ther 58(1510): 160-5
  2. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 42-3
  3. Hamilton (2020) Tarascon Pocket Pharmacopoeia

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Cost: Medications

vraylar (on 1/14/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
VRAYLAR 1.5 MG CAPSULE $41.98 each
VRAYLAR 3 MG CAPSULE $41.94 each
VRAYLAR 4.5 MG CAPSULE $41.93 each
VRAYLAR 6 MG CAPSULE $41.87 each