Coronaviridae

Aka: Coronaviridae, Coronaviridae Infection, Coronavirus, Human Torovirus

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II. Pathophysiology

  1. Coronaviridae are a family of enveloped RNA Viruses with a helical capsid
  2. Coronaviridae are Message Sense RNA Viruses (Positive Stranded, +ssRNA)
    1. Message sense RNA (+ssRNA) are identical to Messenger RNA (mRNA)
    2. Like mRNA, +ssRNA may be immediately translated by host ribosomes into Protein

III. Types: Genera in the Coronaviridae Family

  1. Coronavirus
    1. Mild Upper Respiratory Infections (Common Cold)
      1. Nearly identical presentation to Rhinovirus
      2. Coronavirus causes 15% of adult Common Colds
    2. Major Coronavirus outbreaks with severe morbidity and mortality
      1. Corona Virus 19 (Covid19, SARS-CoV2)
      2. Severe Acute Respiratory Syndrome (SARS)
      3. Middle East Respiratory Syndrome (MERS)
  2. Human Torovirus
    1. Viral Gastroenteritis with acute and persistent Diarrhea (esp. children)
    2. First identified in 1984 as a cause of nosocomial Diarrhea

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