II. Indications
- Acute Lymphoblastic Leukemia (Philadelphia Chromosome negative, relapsing)
III. Contraindications
- Do NOT use via any route other than intravenously
- Do NOT confuse with standard Vincristine
IV. Mechanism
- See Mitotic Inhibitor Chemotherapy
- Liposomal formulation of Vincristine
- Reduced toxicity and better efficacy
-
Vincristine, like Vinblastine, is a natural Vinca Alkaloid with antineoplastic activity
- Isolated from the periwinkle plant (Vinca rosea Linn)
-
Vincristine is an antitubular agent
- Binds tubulin and inhibits microtubule formation
- Disrupts mitotic spindle formation
- Arrests cell cycle in G2/M phase
- Other possible activity
- Interferes with metabolism of Amino Acids cAMP, glutathione
- Interferes with calmodulin-dependent Calcium transport ATPase activity
- Interferes with biosynthesis of Nucleic Acids and lipids
V. Medications
- Vincristine Sulfate Liposome (Marqibo) available as an injection kit
VI. Dosing
- See other references for disease specific dosing protocols
- Only use intravenously (other routes may be lethal)
VII. Pharmacokinetics
- Hepatic metabolism
- Excreted in the stool
VIII. Adverse Effects
- See Vincristine
IX. Safety
- Avoid in Lactation
- Avoid in pregnancy (all trimesters)
- Use reliable Contraception
X. Resources
- Vincristine Injection Solution (DailyMed)
- Vincristine (StatPearls)