Skin Discoloration

Aka: Skin Discoloration, Skin Pigment Changes, Pigmentation Disorder

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II. Causes: Pigmentation Disorders

  1. Hypopigmentation
    1. Vitiligo
    2. Pityriasis Alba
    3. Tinea Versicolor
    4. Postinflammatory Hypopigmentation
  2. Hyperpigmentation
    1. Postinflammatory Hyperpigmentation
    2. Melasma
    3. Solar Lentigines
    4. Ephelides
    5. Cafe Au Lait Macules

III. Causes: Brown discoloration

  1. See Brown Skin Lesion (or Black Skin Lesion)
  2. See Diffuse Hyperpigmentation
  3. Melanism
  4. Hemosiderin (Hemochromatosis)
  5. Wilson's Disease
  6. Venous Stasis Dermatitis

IV. Causes: Blue-Gray discoloration

  1. Silver Poisoning (Argyria)
  2. Arsenic Poisoning
  3. Gold Therapy (Chrysoderma)
  4. Amiodarone
  5. Minocycline-Induced Hyperpigmentation
  6. Alkaptonuria (Ochronosis)

V. Causes: Yellow discoloration

  1. Jaundice
  2. Carotenemia
  3. Medications (Quinacrine)
  4. Explosive manufacture (Dinitrophenol, Tetryl)

VI. References

  1. Gauer (2026) Am Fam Physician 113(5): 495-6 [PubMed]

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