II. Epidemiology

  1. Prevalence: <1%
  2. More common in white patients
  3. Age of onset >40 years

III. Symptoms

  1. Typically asymptomatic
  2. May rarely bleed or be pruritic

IV. Signs

  1. Red-blue Papules
  2. Typically 1-2 mm in size
  3. Distribution
    1. Clustered on the glans penis, often linear along the margin
    2. May occur on Scrotum, groin, thighs, and abdominal wall
    3. Lesions on the penile shaft, suprapubic region or Sacrum suggest Fabry disease and require referral (see below)

V. Differential Diagnosis

  1. Pearly Penile Papules
  2. Fabry Disease (Lysosomal Storage Disease)
    1. May present with Angiokeratomas on the penile shaft, suprapubic region or Sacrum
    2. Requires urgent Consultation

VI. Management: Symptomatic Cases

  1. Electrocautery
  2. Cryotherapy
  3. Laser ablation
  4. Surgical excision

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