I. Rim Pattern

II. Homogenous Pattern

III. Speckled Pattern

  1. Most common, least specific
  2. Disorders
    1. Systemic Lupus Erythematosus
    2. Mixed Connective Tissue Disease
    3. Scleroderma
    4. Sjogren's Syndrome
  3. Further evaluation
    1. Smith Antibody (Anti-Smith)
    2. Ribonucleoprotein Antibody (Anti-RNP)
    3. Scl-70 kD kinetochore (Anti-Topoisomerase I)
    4. Anti-La (Anti-SSB)

IV. Nucleolar Pattern

  1. Disorders
    1. Scleroderma
    2. CREST syndrome
  2. Further evaluation
    1. Scl-70 kD kinetochore (Anti-Topoisomerase I)
    2. PM-1

V. Diffuse Pattern

  1. Non-specific pattern

VI. Centromere Pattern

  1. Seen in PSS with CREST syndrome

VII. References

  1. Gladman in Klippel (1997) Rheumatic Diseases p. 255-6
  2. Peng in Ruddy (2001) Kelley's Rheumatology, p. 161-72
  3. Callegari (1995) Postgrad Med, 97(4):65-74 [PubMed] (or open in [QxMD Read])
  4. Lane (2002) Am Fam Physician 65(6):1073-80 [PubMed] (or open in [QxMD Read])

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Ontology: Nuclear Antibody pattern.homogeneous (C0807128)

Concepts Laboratory or Test Result (T034)
English DIFFUSE ANA PATTERN, HOMOGENEOUS ANTI NUCLEAR ANTIBODY PATTERN, Nuclear Ab pattern.homogeneous, Nuclear Antibody pattern.homogeneous