Rheumatology Book

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ANA Staining PatternAka: ANA Rim Pattern, ANA Homogenous Pattern, ANA Speckled Pattern, ANA Nucleolar Pattern, ANA Diffuse Pattern, ANA Centromere Pattern

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  1. Rim Pattern
    1. Systemic Lupus Erythematosus (Most Specific)
  2. Homogenous Pattern
    1. Systemic Lupus Erythematosus (Very specific)
    2. Further evaluation
      1. Anti-dsDNA
      2. Anti-ssDNA
      3. Anti-Smith
  3. Speckled Pattern
    1. Most common, least specific
    2. Disorders
      1. Systemic Lupus Erythematosus
      2. Mixed Connective Tissue Disease
      3. Scleroderma
      4. Sjogren's Syndrome
    3. Further evaluation
      1. Smith Antibody (Anti-Smith)
      2. Ribonucleoprotein Antibody (Anti-RNP)
      3. Scl-70 kD kinetochore (Anti-Topoisomerase I)
      4. Anti-La (Anti-SSB)
  4. Nucleolar Pattern
    1. Disorders
      1. Scleroderma
      2. CREST syndrome
    2. Further evaluation
      1. Scl-70 kD kinetochore (Anti-Topoisomerase I)
      2. PM-1
  5. Diffuse Pattern
    1. Non-specific pattern
  6. Centromere Pattern
    1. Seen in PSS with CREST syndrome
  7. References
    1. Gladman in Klippel (1997) Rheumatic Diseases p. 255-6
    2. Peng in Ruddy (2001) Kelley's Rheumatology, p. 161-72
    3. Callegari (1995) Postgrad Med 97(4):65
    4. Lane (2002) Am Fam Physician 65(6):1073

Nuclear Antibody pattern.homogeneous (C0807128)

ConceptsLaboratory or Test Result (T034)
EnglishDIFFUSE ANA PATTERN, HOMOGENEOUS ANTI NUCLEAR ANTIBODY PATTERN, Nuclear Ab pattern.homogeneous, Nuclear Antibody pattern.homogeneous
SourcesDXP, LNC
Derived from the NIH UMLS (Unified Medical Language System)



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