Rheumatology Book

Environmental Injury

Thromboangiitis

Vasculitis

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Microscopic Polyangiitis

Aka: Microscopic Polyangiitis, Microscopic Polyarteritis, Leukocytoclastic Vasculitis, Hypersensitivity Vasculitis
  1. See Also
    1. Small Vessel Vasculitis
  2. Epidemiology
    1. Most common ANCA-associated Small Vessel Vasculitis
    2. Age of onset peaks at 40 to 60 years
    3. Gender: Men more commonly affected
  3. Symptoms
    1. Fever
    2. Arthralgias and Myalgias
    3. Cough (Hemoptysis may be present)
  4. Signs
    1. Renal involvement most common (Glomerulonephritis)
    2. Palpable Purpura
    3. Lung disease (pulmonary hemorrhage)
  5. Differential Diagnosis
    1. Polyarteritis Nodosa
    2. ANCA-associated Small Vessel Vasculitis
      1. Especially pulmonary-renal syndromes
      2. Wegener's Granulomatosis
      3. Systemic Lupus Erythematosus
      4. Anti-glomerular basement membrane disease
  6. Labs
    1. Antineutrophil Cytoplasmic Antibody (ANCA)
      1. pANCA (MPO-ANCA) positive in 60-85% of cases
      2. cANCA (PR3-ANCA) positive in 40% of cases
  7. Diagnostics
    1. Biopsy shows minimal to no immune vascular deposits
  8. Management
    1. Same as Wegener's Granulomatosis
  9. References
    1. Calabrese in Ruddy (2001) Kelly's Rheum, p. 1176-8
    2. Schoen in Cotran (1999) Robbins Pathology, p. 521-2

Microscopic Polyangiitis (C0343192)

Definition (MSH) A primary systemic vasculitis of small- and some medium-sized vessels. It is characterized by a tropism for kidneys and lungs, positive association with anti-neutrophil cytoplasmic antibodies (ANCA), and a paucity of immunoglobulin deposits in vessel walls.
Concepts Disease or Syndrome (T047)
MSH D055953
ICD10 M31.7
SnomedCT 239928004
English Microscop polyarteritis nodosa, microscopic polyarteritis nodosa, microscopic polyarteritis nodosa (diagnosis), Polyangiitides, Microscopic, Microscopic Polyangiitides, Polyangiitis, Microscopic, Microscopic Polyangiitis, Microscopic Polyangiitis [Disease/Finding], microscopic polyangiitis, polyarteritis nodosa microscopic, microscopic nodosa polyarterities, Microscopic polyangiitis, Microscopic polyarteritis nodosa, Microscopic polyarteritis nodosa (disorder)
Japanese 顕微鏡的多発血管炎, ｹﾝﾋﾞｷｮｳﾃｷﾀﾊﾂｹｯｶﾝｴﾝ
Czech Mikroskopická polyangiitida, mikroskopická polyangiitida
Korean 현미경적 다발혈관염
French Polyangéite microscopique, Polyangite microscopique
German Mikroskopische Polyangiitis, mikroskopische Polyangiitis
Italian Poliangite microscopica
Portuguese Poliangiite Microscópica, Poliangite microscópica
Spanish Poliangitis Microscópica, Poliangitis Microscopica, poliangiítis microscópica (trastorno), poliangiítis microscópica, poliarteritis nudosa microscópica (trastorno), poliarteritis nudosa microscópica, Poliangitis microscópica
Russian POLIANGIIT MIKROSKOPICHESKII, ПОЛИАНГИИТ МИКРОСКОПИЧЕСКИЙ, МИКРОСКОПИЧЕСКИЙ ПОЛИАНГИИТ, MIKROSKOPICHESKII POLIANGIIT
Swedish Mikroskopisk polyangiit
Polish Zapalenie małych naczyń
Hungarian Mikroszkópos polyangiitis
Dutch microscopische polyangiïtis
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Vasculitis, Leukocytoclastic, Cutaneous (C0151436)

Definition (MSH) Disorder characterized by a vasculitic syndrome associated with exposure to an antigen such as a drug, infectious agent, or other foreign or endogenous substance. Its pathophysiology includes immune complex deposition and a wide range of skin lesions. Hypersensitivity or allergy is present in some but not all cases.
Concepts Disease or Syndrome (T047)
MSH D018366, D014658
ICD9 446.20, 446.2
ICD10 M31.0, D69.0
SnomedCT 195352009, 60555002, 195350001
English Allergic cutaneous arteriolitis, Dermatitis nodularis necroticans, Benign leukocytoclastic vasculitis, Gougerot-Ruiter syndrome, Hypersensitivity Vasculitis, ANGIITIS, HYPERSENSITIVITY, ANGIITIS, LEUKOCYTOCLASTIC, Allergic cutaneous vasculitis, Angiitides, Hypersensitivity, Angiitis, Hypersensitivity, HYPERSENSITIVITY ANGIITIS, Hypersensitivity Angiitides, Hypersensitivity Angiitis, Hypersensitivity Vasculitides, VASCULITIDES, HYPERSENSITIVITY, VASCULITIS ALLERGIC, VASCULITIS, ALLERGIC, VASCULITIS, LEUKOCYTOCLASTIC, Vasculitides, Hypersensitivity, Hypersensitivity angiitis NOS, Hypersensitivity angiitis, unspecified, VASCULITIS NONSPECIFIC ALLERGIC <HYPERSENSITIVITY VASCULITIS>, Hypersensitivity angiitis syndrome, hypersensitivity vasculitis (diagnosis), hypersensitivity angiitis, hypersensitivity vasculitis, hypersensitivity angiitis (diagnosis), Allergic cutaneous angiitis, Vasculitis allergic, VASCULITIS NONSPECIFIC ALLERGIC HYPERSENSITIVITY VASCULITIS, Hypersensit angiitis NOS, Allergic Cutaneous Vasculitis, Cutaneous Leukocytoclastic Angiitis, Leukocytoclastic Angiitis, Cutaneous, Vasculitis, Cutaneous Leukocytoclastic, Allergic Cutaneous Angiitides, Cutaneous Allergic Vasculitides, Allergic Vasculitides, Cutaneous, Allergic Vasculitis, Cutaneous, Angiitides, Cutaneous Leukocytoclastic, Leukocytoclastic Vasculitis, Cutaneous, Angiitis, Cutaneous Leukocytoclastic, Cutaneous Leukocytoclastic Vasculitis, Vasculitides, Cutaneous Leukocytoclastic, Cutaneous Vasculitis, Allergic, Cutaneous Angiitis, Allergic, Angiitis, Allergic Cutaneous, Cutaneous Leukocytoclastic Vasculitides, Vasculitis, Allergic Cutaneous, Allergic Cutaneous Vasculitides, Cutaneous Vasculitides, Allergic, Allergic Cutaneous Angiitis, Vasculitis, Hypersensitivity, Cutaneous Leukocytoclastic Angiitides, Vasculitides, Allergic Cutaneous, Cutaneous Allergic Vasculitis, Vasculitides, Cutaneous Allergic, Vasculitis, Cutaneous Allergic, Leukocytoclastic Angiitides, Cutaneous, Leukocytoclastic Vasculitides, Cutaneous, Angiitides, Allergic Cutaneous, Cutaneous Angiitides, Allergic, Hypersensitivity angiitis NOS (disorder), Vasculitis, Leukocytoclastic, Cutaneous [Disease/Finding], allergic vasculitis, leukocytoclastic angiitis, leukocytoclastic vasculitis, leucocytoclastic vasculitis, vasculitis leukocytoclastic, Vasculitis, Leukocytoclastic, Cutaneous, Hypersensitivity angiitis, Hypersensitivity vasculitis, Allergic vasculitis, Leukocytoclastic vasculitis, Leucocytoclastic angiitis, Leucocytoclastic vasculitis, Maladie trisymptome, Trisymptome, Hypersensitivity angiitis (disorder), Leukocytoclastic angiitis, hypersensitivity; angiitis, allergic; vasculitis, angiitis; hypersensitivity, vasculitis; allergic, Vasculitis, allergic
French ANGEITE ALLERGIQUE, Vasculite d'hypersensibilité, Angéite d'hypersensibilité, non précisée, Angéite cutanée allergique, Angéite allergique, Angéite d'hypersensibilité, Vascularite leucocytoclasique cutanée, Vascularite allergique cutanée, Vascularite allergique, Angéite leucocytoclasique, Vascularite leucocytoclasique, Vascularite d'hypersensibilité, Vasculite allergique
Dutch allergische cutane angiïtis, allergische vasculitis, overgevoeligheidsvasculits, overgevoeligheidsangiïtis, overgevoeligheidsangiïtis, niet-gespecificeerd, allergisch; vasculitis, angiitis; overgevoeligheid, overgevoeligheid; angiitis, vasculitis; allergisch, Angiitis, leukocytoclastische, Angiitis, overgevoeligheids-, Overgevoeligheidsangiitis, Overgevoeligheidsvasculitis, Vasculitis, leukocytoclastische, Vasculitis, overgevoeligheids-
German allergische kutane Angiitis, allergische Vaskulitis, Hypersensitivitaetsvaskulitis, anaphylaktische Angiitis, Vaskulitis allergisch, Hypersensitivitaetsangiitis, unspezifisch, Hypersensitivitaetsangiitis, VASKULITIS ALLERGISCH, Angiitis, leukozytoklastische, Leukozytoklastische Vaskulitis, Vaskulitis, leukozytoklastische, Angiitis, Hypersensitivitäts-, Hypersensitivitätsangiitis, Hypersensitivitätsvaskulitis, Vaskulitis, Hypersensitivitäts-
Italian Angioite da ipersensibilizzazione non specificata, Vasculite da ipersensibilità, Vasculite allergica, Angioite da ipersensibilizzazione, Angioite cutanea allergica, Vasculite leucocitoclastica cutanea
Portuguese Vasculite alérgica, Angeíte cutânea alérgica, Angeíte por hipersensibilidade NE, Angeíte por hipersensibilidade, Vasculite por hipersensibilidade, VASCULITE ALERGICA, Vasculite de Hipersensibilidade, Vasculite Leucocitoclástica Cutânea, Angiite de Hipersensibilidade
Spanish Vasculitis alérgica, Vasculitis por hipersensibilidad, Angeítis cutánea alérgica, Angeítis por hipersensibilidad, Angeítis por hipersensibilidad no especificada, VASCULITIS ALERGICA, Vasculitis Leucocitoclástica Cutánea, Vasculitis Leucocitoclastica Cutanea, Vasculitis por Hipersensibilidad, angiítis por hipersensibilidad, angeítis por hipersensibilidad, SAI (trastorno), angeítis por hipersensibilidad, SAI, angeítis por hipersensibilidad, vasculitis alérgica, vasculitis leucocitoclástica (trastorno), vasculitis leucocitoclástica, vasculitis por hipersensibilidad, Angitis por Hipersensibilidad
Japanese 過敏性脈管炎、詳細不明, ｶﾋﾞﾝｾｲｹｯｶﾝｴﾝ, ｱﾚﾙｷﾞｰｾｲﾋﾌｹｯｶﾝｴﾝ, ｶﾋﾞﾝｾｲﾐｬｸｶﾝｴﾝｼｮｳｻｲﾌﾒｲ, ｱﾚﾙｷﾞｰｾｲｹｯｶﾝｴﾝ, 血管炎-過敏性, 血管炎-皮膚アレルギー性, 皮膚白血球破砕性血管炎, アレルギー性血管炎, アレルギー性皮膚血管炎, 皮膚アレルギー性血管炎, アレルギー性皮膚脈管炎, 血管炎-アレルギー性皮膚, 血管炎-皮膚白血球破砕性, 白血球破砕性脈管炎, 白血球破砕性血管炎, 過敏性脈管炎, 過敏性血管炎, 脈管炎-白血球破砕性, 脈管炎-過敏性, 血管炎-アレルギー性
Czech angiitida z hypersenzitivity, Alergická kožní angiitida, Hypersenzitivní angiitida, Alergický zánět cév, Hypersenzitivní vaskulitida, Hypersenzitivní angiitida, blíže neurčená, Alergická vaskulitida, vaskulitida leukocytoklastická kožní, angiitida leukocytoklastická kožní, vaskulitida alergická
Finnish Allerginen verisuonitulehdus, Ihon allerginen vaskuliitti
Russian VASKULIT ALLERGICHESKII, ANGIIT, GIPERSENSIBILIZATSIIA, VASKULIT, GIPERSENSIBILIZATSIIA, АЛЛЕРГИЧЕСКИЙ КОЖНЫЙ АНГИИТ, ALLERGICHESKII KOZHNYI ANGIIT, АЛЛЕРГИЧЕСКИЙ КОЖНЫЙ ВАСКУЛИТ, ВАСКУЛИТ АЛЛЕРГИЧЕСКИЙ КОЖНЫЙ, VASKULIT LEIKOTSITOKLASTICHESKII KOZHNYI, ВАСКУЛИТ АЛЛЕРГИЧЕСКИЙ, ALLERGICHESKII KOZHNYI VASKULIT, АНГИИТ АЛЛЕРГИЧЕСКИЙ КОЖНЫЙ, ANGIIT ALLERGICHESKII KOZHNYI, VASKULIT ALLERGICHESKII KOZHNYI, ВАСКУЛИТ ЛЕЙКОЦИТОКЛАСТИЧЕСКИЙ КОЖНЫЙ, АНГИИТ, ГИПЕРСЕНСИБИЛИЗАЦИЯ, ВАСКУЛИТ, ГИПЕРСЕНСИБИЛИЗАЦИЯ
Korean 과민성 혈관염
Swedish Vaskulit, allergisk, kutan
Polish Alergiczne zapalenie naczyń, Zapalenie naczyń skóry z nadwrażliwości, Zapalenie naczyń na tle nadwrażliwości, Zapalenie małych naczyń skóry, Zapalenie naczyń leukocytoklastyczne, Leukocytoklastyczne zapalenie naczyń
Hungarian Allergiás vasculitis, Hypersensitivitas angiitis, Vasculitis, allergiás, Allergiás cutan angiitis, Hypersensitivitas angiitis, nem meghatározott, Hypersensitivitas vasculitis
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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