Rheumatology Book

Environmental Injury

Miscellaneous

Vasculitis

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Microscopic PolyangiitisAka: Microscopic Polyarteritis, Leukocytoclastic Vasculitis, Hypersensitivity Vasculitis

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  1. See Also
    1. Small Vessel Vasculitis
  2. Epidemiology
    1. Most common ANCA-associated Small Vessel Vasculitis
    2. Age of onset peaks at 40 to 60 years
    3. Gender: Men more commonly affected
  3. Symptoms
    1. Fever
    2. Arthralgias and Myalgias
    3. Cough (Hemoptysis may be present)
  4. Signs
    1. Renal involvement most common (Glomerulonephritis)
    2. Palpable Purpura
    3. Lung disease (pulmonary hemorrhage)
  5. Differential Diagnosis
    1. Polyarteritis Nodosa
    2. ANCA-associated Small Vessel Vasculitis
      1. Especially pulmonary-renal syndromes
      2. Wegener's Granulomatosis
      3. Systemic Lupus Erythematosus
      4. Anti-glomerular basement membrane disease
  6. Labs
    1. Antineutrophil Cytoplasmic Antibody (ANCA)
      1. pANCA (MPO-ANCA) positive in 60-85% of cases
      2. cANCA (PR3-ANCA) positive in 40% of cases
  7. Diagnostics
    1. Biopsy shows minimal to no immune vascular deposits
  8. Management
    1. Same as Wegener's Granulomatosis
  9. References
    1. Calabrese in Ruddy (2001) Kelly's Rheum, p. 1176-8
    2. Schoen in Cotran (1999) Robbins Pathology, p. 521-2

Hypersensitivity vasculitis (C0151436)

Definition (MSH)Heterogeneous group of disorders characterized by a vasculitic syndrome presumed to be associated with a hypersensitivity reaction following exposure to an antigen such as an infectious agent, a drug, or other foreign or endogenous substance (Wilson et al, Harrison's Principles of Internal Medicine, 12th ed, p1459).
ConceptsDisease or Syndrome (T047)
ICD9287.0, 446.2, 446.20
MSHD018366
EnglishAllergic vasculitis, Hypersensitivity Angiitides, Hypersensitivity angiitis, Hypersensitivity Vasculitides, Hypersensitivity vasculitis, Leucocytoclastic angiitis, Leucocytoclastic vasculitis, Leukocytoclastic Angiitides, Leukocytoclastic angiitis, Leukocytoclastic Vasculitides, Leukocytoclastic vasculitis, Maladie trisymptome, Trisymptome, VASCULITIS ALLERGIC, VASCULITIS NONSPECIFIC ALLERGIC <HYPERSENSITIVITY VASCULITIS>, VASCULITIS NONSPECIFIC ALLERGIC HYPERSENSITIVITY VASCULITIS
Spanishangeitis por hipersensibilidad, angiitis por hipersensibilidad, vasculitis alergica, vasculitis leucocitoclastica, vasculitis por hipersensibilidad
Parent ConceptsExaminer's Diagnosis (C0178413), Hypersensitivity vasculitis (C0151436), Polyarteritis nodosa and allied conditions NOS (C0155757), Immune Complex Diseases (C0020951), Vasculitis (C0042384), Allergic disorder by body site affected (C1720649), Ambiguous concept (C1274012)
SourcesAIR, COSTAR, CST, DXP, ICD9CM, MSH, MTH, MTHICD9, NDFRT, QMR, RAM, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)


Microscopic polyarteritis nodosa (C0343192)

ConceptsDisease or Syndrome (T047)
EnglishMicroscopic polyangiitis, Microscopic polyarteritis nodosa
Spanishpoliangiitis microscopica, poliarteritis nudosa microscopica
Parent ConceptsPolyarteritis Nodosa (C0031036), Primary necrotizing systemic vasculitis (C0343188), Necrosis of artery (C0155762), Systemic arterial finding (C0577829)
SourcesSCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)



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