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Antineutrophil Cytoplasmic AntibodyAka: Antineutrophil Cytoplasmic Antibodies, ANCA, Proteinase 3-ANCA, PR3-ANCA, Myeloperoxidase-ANCA, MPO-ANCA

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  1. See Also
    1. Antinuclear Antibody
    2. Small Vessel Vasculitis
  2. Indications
    1. Small Vessel Vasculitis
    2. Wegener's Granulomatosis suspected (cANCA)
  3. Mechanism
    1. Antibodies bind to cytoplasmic region of Neutrophils
  4. Testing
    1. Cytospin preparations of Neutrophils are permeabilized
    2. Binding of serum antibodies assessed as with ANA
  5. Results
    1. C-ANCA (Cytoplasmic: PR3-ANCA)
      1. Classic, Diffuse, fine granular cytoplasmic staining
      2. Antibodies directed to Proteinase-3 antigen (PR3)
    2. P-ANCA (Peri-nuclear: MPO-ANCA)
      1. Perinuclear pattern
      2. Antibodies to Myeloperoxidase (MPO)
  6. Associated Conditions
    1. C-ANCA or PR3-ANCA
      1. Wegener's Granulomatosis (Very Strongly associated)
        1. Positive in 75-98% of patients with Wegener's
        2. Sensitivity drops to 30% during remission
      2. Crescentic Glomerulonephritis (moderately associated)
      3. Polyarteritis nodosa (Weakly associated)
    2. P-ANCA or MPO-ANCA
      1. Crescentic Glomerulonephritis (Strongly associated)
      2. Polyarteritis nodosa (Moderately associated)
      3. Churg-Strauss Vasculitis (Moderately associated)
      4. Wegener's Granulomatosis (Weakly associated)
      5. Henoch-Schonlein Purpura (Possibly associated)
      6. Temporal Arteritis (Possibly associated)
  7. References
    1. Gladman in Klippel (1997) Rheumatic Diseases p. 255-6
    2. Peng in Ruddy (2001) Kelley's Rheumatology, p. 161-72
    3. Callegari (1995) Postgrad Med 97(4):65
    4. Lane (2002) Am Fam Physician 65(6):1073

Antineutrophil Cytoplasmic Antibodies (C0103647)

Definition (MSH)Autoantibodies directed against cytoplasmic constituents of POLYMORPHONUCLEAR LEUKOCYTES and/or MONOCYTES. They are used as specific markers for WEGENER GRANULOMATOSIS and other diseases, though their pathophysiological role is not clear. ANCA are routinely detected by indirect immunofluorescence with three different patterns: c-ANCA (cytoplasmic), p-ANCA (perinuclear), and atypical ANCA.
ConceptsImmunologic Factor (T129)
MSHD019268
EnglishANCA, ANCA - Anti-neutrophil cytoplasmic antibody, Anti Neutrophil Cytoplasmic Antibodies, Anti Neutrophil Cytoplasmic Antibody, Anti neutrophilic cytoplasm antibody, Anti-Neutrophil Cytoplasmic Antibodies, Anti-neutrophil cytoplasmic antibody, Antineutrophil Cytoplasmic Antibodies, Antineutrophil Cytoplasmic Antibody, Neutrophil cytoplasmic Ab, Neutrophil cytoplasmic antibody
Spanishanticuerpo anti citoplasma neutrofilico, anticuerpo citoplasmatico antineutrofilo
Parent ConceptsAutoantibodies (C0004358), Biological Markers (C0005516), Cytoplasmic antibody (C0312620), Granulocyte antibody (C0312629)
SourcesLNC, MSH, MTH, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)



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