Mental Health Book

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QuazepamAka: Doral

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  1. See Also
    1. Benzodiazepine
  2. Class
    1. Long acting Benzodiazepine
  3. Indications
    1. Insomnia
  4. Dose
    1. Insomnia
      1. 7.5-30 mg PO qhs
    2. Anxiety
      1. Maximum Daily Dose: 15 mg
  5. Pharmacokinetics
    1. Half-Life: 39 hours
  6. Background
    1. Weekly Cost: $5.08

quazepam (C0072828)

Definition (NCI)A synthetic benzodiazepine derivative with anxiolytic, sedative and hypnotic properties. Quazepam and its major metabolite 2-oxoquazepam potentiate gamma-aminobutyric acid (GABA) activity by binding to the benzodiazepine-1 recognition site (BZ-1) within the GABA-A receptor, located in the limbic, neocortical and mesencephalic reticular system. This increases the frequency of GABA-activated chloride channel opening events, allowing the flow of chloride ions into the neuron leading to membrane hyperpolarization and decreased neuronal excitability.
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHC025130
Englishquazepam, QUAZEPAM PREPARATION, Quazepam product
Spanishcuacepam, cuazepam
Parent ConceptsBenzodiazepines (C0005064), [CN302] BENZODIAZEPINE DERIVATIVE, SEDATIVES/HYPNOTICS (C0973503), Unclassified Ingredients (C1372954), Benzodiazepine sedative (C0360114)
SourcesLNC, MSH, NCI, NDFRT, RXNORM, SCTSPA, SNOMEDCT, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


Doral (C0720023)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHC025130
EnglishDoral, Wallace brand of quazepam
SourcesMSH, NCI, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)



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