Mental Health Book

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Intranasal NicotineAka: Nicotine Nasal Spray, Nicotrol NS

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  1. See Also
    1. Tobacco Abuse
    2. Nicotine Replacement
  2. Indications
    1. Tobacco Cessation
  3. Efficacy
    1. One year quit rate 25% (12% for Placebo)
    2. Best in obese heavy smokers and non-white patients
      1. Lerman (2004) Ann Intern Med 140:426
  4. Mechanism
    1. Rapidly absorbed via nasal mucosa
  5. Preparation
    1. Concentration 10 mg/ml and provides 0.5 mg/spray
    2. Each bottle contains 10 ml
  6. Dosing
    1. One dose is 1 spray each nostril (1 mg Nicotine)
    2. Use 1-2 doses per hour while awake for 8 weeks
    3. Taper over the next month
    4. Minimum recommended: 8 doses (8 mg) per day
    5. Maximum: 40 doses (40 mg) per day
    6. Do not use more than 6 months total
  7. Risks
    1. Greater abuse potential than Nicotine Patch or gum
  8. Contraindications
    1. Same as Nicotine Patch
    2. Bronchospasm
  9. Adverse Effects
    1. Nasal Irritation (90%): Rhinorrhea or sneezing
    2. Throat irritation
    3. Nausea
    4. Watery eyes
    5. Cough

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