Neurology Book

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VecuroniumAka: Norcuron

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  1. See Also
    1. Paralytic Agent
  2. Precautions
    1. Used only in anesthesia, emergency and intensive care
    2. Airway and respiratory control is critical after use
    3. Paralytic Agents do not alter Level of Consciousness
      1. Must be used with Sedation and analgesia
  3. Indication
    1. Paralysis in Rapid Sequence Intubation
  4. Mechanism
    1. Non-depolarizing Neuromuscular Blocking Agent
    2. Structurally similar to Pancuronium
      1. Same steroid nucleus
      2. Tertiary Nitrogen at position 2 is only difference
    3. Significantly different effects than Pancuronium
      1. Duration of action is half that of Pancuronium
      2. Hepatic excretion predominates
      3. Minimal cardiovascular effects
  5. Dose
    1. Initial Dose
      1. Vecuronium alone: 0.08 to 0.1 mg/kg IV
      2. Vecuronium after Succinylcholine: 0.04 to 0.06 mg/kg
    2. Maintenance dosing (if needed)
      1. Starts 25-40 minutes after initial dose
      2. Please see other references for maintenance dosing
    3. Reduce dosage in hepatic Impairment
    4. Do not use by intramuscular dosing
  6. Pharmacokinetics
    1. Onset: 1-2 minutes
    2. Maximal Neuromuscular Blockade by 3-5 minutes
    3. Duration: 30 minutes
  7. References
    1. Miller in Katzung (1989) Pharmacology, p. 323-33
    2. Savarese in Miller (2000) Anesthesia, p. 412-90
    3. (2003) Lexicomp Drug database for Pocket PC

Vecuronium (C0242531)

ConceptsSteroid (T110) , Pharmacologic Substance (T121)
MSHD014673
EnglishVecuronium, VECURONIUM PREPARATION
Spanishvecuronio
Parent ConceptsNeuromuscular Blocking Agents (C0027866), Nondepolarizing agent (C0304435), Steroidal neuromuscular blocker (C1631057), Skeletal Muscle Relaxants (C0037250)
SourcesLNC, MSH, NDFRT, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


Norcuron (C0700018)

ConceptsSteroid (T110) , Pharmacologic Substance (T121)
MSHD014673
EnglishNorcuron
SourcesMSH, NCI, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)



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