II. Definition

  1. Arthritis secondary to Mycobacterium tuberculosis

III. Epidemiology

  1. Represents 35% of Extrapulmonary Tuberculosis

IV. Distribution

  1. Spinal Tuberculosis (Pott's Disease)
    1. Thoracic Spine most commonly involved
    2. Associated with paraspinous abscess
    3. Destroys anterior Vertebral body and adjacent disc
      1. Results in anterior wedging
      2. Forms prominence of spine known as Gibbus
      3. May compress central cord
  2. Articular Tuberculosis (most common involvement)
    1. Monoarticular Arthritis of weight bearing joints
    2. Presents with insidious monoarticular pain, swelling
    3. May form superficial abscesses and drain to skin
  3. Poncet's Disease (rare)
    1. Acute sterile Polyarthritis
    2. Associated with visceral involvement
  4. Tuberculous Osteomyelitis
    1. May involve any bone

V. Signs

  1. Doughy synovitis on joint palpation

VII. Radiology: Chest XRay

  1. Pulmonary involvement in only 50% of Tb arthritis

VIII. Diagnosis

  1. Arthrocentesis with Mycobacterium tuberculosis culture
    1. Test Sensitivity: 80%
  2. Synovial biopsy

IX. Management

  1. See Extrapulmonary Tuberculosis
  2. See Tuberculosis Management
  3. Four drug regimen
    1. Isoniazid for 10 to 24 months
    2. Rifampin for 10 to 24 months
    3. Pyrazinamide for 2 months
    4. Ethambutol until Tuberculosis sensitivity established
    5. Atypical Mycobacteria require fifth drug added
      1. Azithromycin or
      2. Clarithromycin

Images: Related links to external sites (from Google)

Ontology: Joint Tuberculosis (C0022415)

Concepts Disease or Syndrome (T047)
MSH D014394
ICD10 M01.1 , A18.01
SnomedCT 201556004, 7023007, 63712002, 367488007, 190710003, 186229002
English Joint Tuberculoses, Tuberculoses, Joint, Tuberculous Arthritis, ARTHRITIS, TUBERCULOUS, Tuberculosis, Joint, Tuberculosis of joint, NOS, Tuberculous arthropathy (disorder), tuberculosis of a joint, tuberculosis of joint, tuberculosis of joint (diagnosis), joint tuberculosis, joints tuberculosis, Tuberculosis;joint(s), tuberculous arthritis, of joint tuberculosis, Joint tuberculosis, Tuberculous arthritis, Tuberculous arthropathy, Tuberculous rheumatism, Tuberculosis of joint, Tuberculosis of joint (disorder), Tuberculous arthritis (disorder), Tuberculosis of joint (disorder) [Ambiguous], Tuberculous arthritis [Ambiguous], Tuberculous arthropathy -RETIRED-, Joint Tuberculosis, TB of the jointe
Italian Tubercolosi articolare, Tubercolosi dell'articolazione
Japanese 関節結核, カンセツケッカク
Portuguese Tuberculose Articular, Tuberculose articular
Spanish Tuberculous arthritis, Tuberculous arthritis [Ambiguous], Tuberculosis Articular, artritis tuberculosa (trastorno), artritis tuberculosa, artropatía tuberculosa - RETIRADO - (concepto no activo), artropatía tuberculosa - RETIRADO -, artropatía tuberculosa, reuma tuberculoso, reumatismo tuberculoso, tuberculosis articular (trastorno), tuberculosis articular, tuberculosis de la articulación (concepto no activo), tuberculosis de la articulación (trastorno), tuberculosis de la articulación, Tuberculosis articular
French Tuberculose articulaire, Tuberculose des articulations
German Gelenktuberkulose, Tuberkuloese Arthritis
Czech Tuberkulóza kloubů
Korean 결핵성 관절염
Hungarian ízületi tuberculosis
Dutch Tuberculeuze artritis, gewrichtstuberculose, Gewrichtstuberculose

Ontology: Kyphosis deformity of spine (C0022821)

Definition (MSH) Deformities of the SPINE characterized by an exaggerated convexity of the vertebral column. The forward bending of the thoracic region usually is more than 40 degrees. This deformity sometimes is called round back or hunchback.
Definition (NCI) Abnormally increased curvature of the thoracic portion of the spine.
Definition (NCI) A disorder characterized by an abnormal increase in the curvature of the thoracic portion of the spine.
Concepts Anatomical Abnormality (T190)
MSH D007738
ICD10 M40.20
SnomedCT 88796005, 298383008, 414564002
English Kyphoses, Kyphosis, KYPHOSIS, Kyphosis, NOS, Angulation of spine, Kyphosis deformity of spine, Unspecified kyphosis, Kyphosis [Disease/Finding], gibbus, kyphosis, hunchback, round back, spine; angulation, angulation; spine, Gibbosity, Gibbus, Humpback, Hunchback, Kyphosis deformity of spine (disorder)
Japanese 脊柱後弯症, セキチュウコウワンショウ
Swedish Kyfos
Spanish giba, cifosis, cifosis (trastorno), joroba, Kyphosis deformity of spine, deformidad de la columna vertebral - cifosis (trastorno), deformidad de la columna vertebral - cifosis, Cifosis
Czech kyfóza, Kyfóza
Finnish Kyfoosi
Croatian KIFOZA
Polish Wygięcie kręgosłupa tylne, Kifoza
Hungarian Kyphosis
Dutch angulatie; wervelkolom, wervelkolom; angulatie, kyfose, Kyfose
French Cyphose
German Kyphose
Italian Cifosi
Portuguese Cifose

Ontology: Tuberculosis, Spinal (C0041330)

Definition (MSH) Osteitis or caries of the vertebrae, usually occurring as a complication of tuberculosis of the lungs.
Concepts Disease or Syndrome (T047)
MSH D014399
ICD9 015.00, 015.0
ICD10 M49.0 , A18.01
SnomedCT 50509001, 203262001, 186230007, 35984006
English Spinal Tuberculoses, Spinal Tuberculosis, Tuberculoses, Spinal, POTT DISEASE, SPINE, TUBERCULOSIS, SPONDYLITIS, TUBERCULOUS, TB vertebral column - Pott's, Tuberculosis of spine, Tuberculosis of vertebral column, unspecified examination, TUBERCULOUS SPONDYLITIS, Pott's disease (diagnosis), Tuberculosis of spine (disorder), Tuberculous spondylitis (disorder), Tuberculosis of spinal cord, TB spine, Tuberculous spine, TB of vertebra-unspec, Tuberculosis, Spinal [Disease/Finding], Tuberculosis of vertebral column, unspecified, spine tuberculosis, disease pott's, pott's disease, potts disease, spinal cord tuberculosis, pott disease, spine tuberculous, tuberculous spondylitis, diseases pott, disease pott, spine tb, tb spine, tuberculosis of spine, tuberculosis spinal, tuberculosis spine, spinal tuberculosis, diseases pott's, disease potts, Pott's Disease, Pott Disease, POTT DIS, POTTS DIS, Disease, Pott's, Disease, Pott, Potts Disease, Tuberculosis, Spinal, Tuberculous spondylitis, Tuberculosis of vertebral column, Pott's disease, Tuberculosis of vertebral column - Pott's, Tuberculosis of spine (Pott's), Tuberculosis of vertebral column (disorder), Pott; disease (etiology), Pott; disease (manifestation), disease (or disorder); spine or vertebra, tuberculous (etiology), disease (or disorder); spine or vertebra, tuberculous (manifestation), spine or vertebra; disorder, tuberculous (etiology), spine or vertebra; disorder, tuberculous (manifestation), Tuberculous spondylitis -RETIRED-
Dutch ziekte van Pott, ruggengraattuberculose, wervelkolomtuberculose, wervelkolomtuberculose, niet-gespecificeerd onderzoek, tuberculeuze ruggengraat, TBC ruggengraat, tuberculose van ruggenmerg, Pott; ziekte, aandoening; wervel{kolom}, tuberculeus, wervel{kolom}; aandoening, tuberculeus, Tuberculose van wervelkolom, Pott, ziekte van, Tuberculose, spinale, Tuberculose, wervelkolom-, Wervelkolomtuberculose, Ziekte van Pott
French TB rachidienne, Tuberculose de la moelle épinière, Rachis tuberculeux, Maladie de Pott, Tuberculose de la colonne vertébrale, examen non précisé, Tuberculose de la colonne vertébrale, Spondylodiscite tuberculeuse, Tuberculose vertébrale, Mal de Pott, Spondylite tuberculeuse, Tuberculose du rachis, Tuberculose rachidienne
German Tuberkulose der Wirbelsaeule, Tuberkulose des Rueckenmarks, TB Wirbelsaeule, Tuberkulose der Wirbelsaeule, unspezifische Untersuchung, tuberkuloese Wirbelsaeule, Spinale Tuberkulose, Tuberkulose, spinale, Pott-Krankheit, Wirbelsäulentuberkulose
Italian Tubercolosi del midollo spinale, Tubercolosi vertebrale, Tubercolosi della colonna vertebrale, esame non specificato, Tubercolosi della colonna vertebrale, Malattia di Pott, Tubercolosi spinale
Portuguese Coluna vertebral com tuberculose, Mal de Pott, TB da coluna, Tuberculose da coluna vertebral, Tuberculose da medula espinhal, Tuberculose da coluna vertebral com exame NE, Doença de Pott, Tuberculose da Coluna Vertebral
Spanish Tuberculosis de la médula espinal, Tuberculosis espinal, Tuberculosis de la columna vertebral, TB de columna, Tuberculosis de columna, Tuberculosis de la columna vertebral, estudio no especificado, Tuberculosis Vertebral, Tuberculosis Espinal, Tuberculosis of spine, enfermedad de Pott, espondilitis tuberculosa - RETIRADO - (concepto no activo), espondilitis tuberculosa - RETIRADO -, espondilitis tuberculosa, tuberculosis de la columna vertebral (trastorno), tuberculosis de la columna vertebral, Enfermedad de Pott, Tuberculosis de la Columna Vertebral
Japanese 脊髄結核, 脊柱結核、検査の詳細不明, 脊柱結核, セキチュウケッカク, セキチュウケッカクケンサノショウサイフメイ, セキツイケッカク, ポットビョウ, セキズイケッカク, 結核-脊椎, Pott病, ポット病, 脊椎結核, 結核性脊椎炎, 脊椎カリエス, 脊椎炎-結核性
Swedish Tuberkulos, spinal
Czech tuberkulóza páteře, Tuberkulóza páteře, blíže neurčené vyšetření, Tuberkulózní zánět páteře, Tuberkulóza páteře, Pottova nemoc, TBC páteře, Tuberkulóza míchy
Finnish Selkärankatuberkuloosi
Korean 척추의 결핵
Polish Gruźlica kręgosłupa, Choroba Potta
Hungarian Gerincoszlop tuberculosisa, gerinc tbc-s fertőzése, Gerincvelő tuberculosisa, gerinctuberculosis, Pott-betegség, Gerinc TBC, Gerincoszlop tuberculosisa, nem meghatározott vizsgálat

Ontology: Tuberculous osteomyelitis (C0275922)

Concepts Disease or Syndrome (T047)
MSH D014394
ICD10 M90.0 , A18.03
SnomedCT 240377007, 203283007, 40138002, 58764007, 38279006, 186229002
English Bone Tuberculoses, Tuberculoses, Bone, OSTEITIS TUBERCULOUS, Tuberculosis, Bone, Tuberculosis of bone, NOS, Tuberculous osteomyelitis, Tuberculosis of bone NOS, tuberculosis of bone (diagnosis), tuberculous osteomyelitis, tuberculosis of bone, tuberculous osteomyelitis (diagnosis), tubercular osteomyelitis, TB bone, Tuberculous bone, Osteitis tuberculous, Tuberculosis of bone NOS (disorder), of tuberculosis bone, tuberculosis bone, Tuberculosis;bone(s), bones tuberculosis, tuberculosis bones, bone tuberculosis, bones tuberculoses, Bone tuberculosis, Tuberculous osteitis, Tuberculosis of bone, Tuberculosis of bone (disorder), Tuberculous osteitis (disorder), Tuberculous osteomyelitis (disorder), osteitis; tuberculosa (etiology), osteitis; tuberculosa (manifestation), osteitis; tuberculous (manifestation), tuberculosa; osteitis (manifestation), tuberculosis; osteitis tuberculosa (etiology), Tuberculosis of bone [Ambiguous], Tuberculous osteomylelytis, Bone Tuberculosis, TB of the bone
Dutch osteitis tuberculeus, tuberculeus bot, TBC bot, osteïtis; tuberculosa, osteïtis; tuberculose, tuberculosa; osteïtis, tuberculose; osteitis tuberculosa, Tuberculose van bot, bottuberculose, Bottuberculose
French Ostéite tuberculeuse, TB osseuse, Os tuberculeux, Tuberculose osseuse, OSTEITE TUBERCULEUSE, Tuberculose des os
German tuberkuloese Ostitis, TB Knochen, tuberkuloeser Knochen, Knochentuberkulose, OSTEITIS TUBERKULOES
Italian Osteite tubercolare, Tubercolosi ossea
Portuguese Osteíte tuberculosa, TB óssea, Osso tuberculoso, Tuberculose Óssea, OSTEITE TUBERCULOSA, Tuberculose óssea
Spanish TB ósea, Osteitis tuberculosa, Tuberculosis of bone, Tuberculosis of bone [Ambiguous], Tuberculous osteomyelitis, Tuberculous arthritis, Tuberculous osteomylelytis, Tuberculosis Osea, Tuberculosis Ósea, OSTEITIS TUBERCULOSA, osteomielitis tuberculosa (trastorno), osteomielitis tuberculosa, osteítis tuberculosa (trastorno), osteítis tuberculosa, tuberculosis del hueso (trastorno), tuberculosis del hueso, tuberculosis ósea, SAI (trastorno), tuberculosis ósea, SAI, tuberculosis ósea, Tuberculosis ósea
Japanese 骨結核, 結核性骨炎, ホネケッカク, ケッカクセイコツエン, コツケッカク
Czech Tuberkulózní osteitis, Tuberkulóza kostí, TBC kostí, Tuberkulózní zánět kosti
Korean 뼈의 결핵
Hungarian Osteitis tuberculosa, csont tuberculosis, Tuberculoticus csont, Csont TBC