Infectious Disease Book

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Rotavirus VaccineAka: RotaShield

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  1. See Also
    1. Rotavirus
  2. Indications
    1. May not be recommended due to Intussusception risk
      1. See adverse risks below
  3. Pharmacokinetics
    1. Oral Tetravalent live virus vaccine
  4. Schedule
    1. Dose 1: age 2 months
    2. Dose 2: age 4 months
    3. Dose 3: age 6 months
  5. Contraindications
    1. Immunocompromised infants
  6. Adverse Effects
    1. Fever after first dose within 3 days
    2. Adverse effects increase after age 12 months
    3. Increased Incidence of Intussusception
      1. Dennehy (2001) Infect Dis Clin North Am 15(1):189
      2. Nakagomi (2001) N Engl J Med 344(24):1866
      3. Zanardi (2001) Pediatrics 107(6):E97
  7. Efficacy
    1. Prevents 50-70% of all Rotavirus cases
    2. Prevents 70-90% of severe Rotavirus cases
    3. Seropositive response: 92%
  8. References
    1. Rennels (1996) Pediatrics 97:7
    2. Santosham (1997) J Pediatr 131:632
    3. Joensuu (1997) Lancet 350:1205
    4. (1999) Med Lett Drugs Ther 41:50

Rotavirus Vaccines (C0597418)

Definition (CSP)vaccines or candidate vaccines used to prevent infection with rotavirus.
Definition (MSH)Vaccines or candidate vaccines used to prevent infection with ROTAVIRUS.
ConceptsAmino Acid, Peptide, or Protein (T116) , Pharmacologic Substance (T121) , Immunologic Factor (T129)
Englishrotavirus vaccine, Rotavirus Vaccines
Spanishvacuna contra rotavirus
CreditsDerived from the NIH UMLS (Unified Medical Language System)


RotaShield (C0723145)

ConceptsPharmacologic Substance (T121) , Immunologic Factor (T129)
EnglishRotaShield
CreditsDerived from the NIH UMLS (Unified Medical Language System)



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