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Cryoprecipitate

Aka: Cryoprecipitate

Preparations
1. Cryoprecipitate
  1. Derived from thawing Fresh Frozen Plasma and collecting precipitate
  2. Contains high concentrations of Factor VIII and Fibrinogen
Indications: Adults
1. Post-cardiac surgery hemorrhage (or other postoperative bleeding)
2. Massive hemorrhage or transfusion
Indications: Newborns
1. Factor VIII Deficiency (if recombinant factor VIII not available)
2. Von Willebrand Disease (if recombinant factors not available)
3. Factor XIII deficiency
4. Congenital Dysfibrinogenemia
5. Congenital Fibrinogen deficiency
Labs
1. Fibrinogen
  1. Expect one unit to raise Fibrinogen 5-10 mg/dl
  2. Goal Fibrinogen >100 mg/dl
Dosing
1. Adults: 10 units Cryoprecipitate (typical)
2. Newborn: variable dosing starting from 2 ml/kg
References
1. Sharma (2011) Am Fam Physician 83(6): 719-24
2. Callum (2009) Transfus Med Rev 23(3):177-88

Family Practice Notebook

Patients should address specific medical concerns with their physicians.

Although access to this page is not restricted, the information found here is intended for use by medical providers.

This page was written by Scott Moses, MD, last revised on 12/1/2011 and last published on 5/17/2012.

This is one of 5740 pages in the Family Practice Notebook