II. Mechanism

  1. Acute phase reactant
  2. Clotting Cascade component
    1. Marker of adequate Hemostasis
    2. Marker in Trauma of Massive Hemorrhage
      1. Lower Fibrinogen level correlates with increased blood loss, need for transfusion, and worse outcomes

III. Labs: Normal

  1. Normal: 200-400 mg/dl (2 to 4 g/L)

IV. Causes: Increased Fibrinogen

  1. Tissue inflammation or damage
  2. Acute infection
  3. Myocardial Infarction
  4. Medications
    1. Oral Contraceptives
  5. Pregnancy

V. Causes: Decreased Fibrinogen

  1. Disseminated Intravascular Coagulation
  2. Primary or Secondary Fibrinolysis
  3. Liver disease
  4. Hereditary afibrinogenemia or Hypofibrinogenemia
  5. Cachexia
  6. Massive Hemorrhage (Trauma)

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