Gastroenterology Book

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MisoprostolAka: Cytotec, PGE1 Gel

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  1. Mechanism
    1. Gastric Mucosa Protection by prostaglandin replacement
  2. Preparations
    1. Misoprostol (Cytotec)
  3. Indication
    1. Peptic Ulcer Disease prevention
      1. Prevents ulcers in those on NSAIDs chronically
    2. Cervical Ripening agent in Pregnancy Labor Induction
  4. Dosing
    1. See Cervical Ripening for pregnancy dosing
    2. Option 1: 100 ug qid with food
    3. Option 2: 200 ug bid with food
      1. Better tolerated than qid dosing
  5. Side Effects
    1. Diarrhea
    2. Poorly tolerated
  6. Efficacy: Peptic Ulcer Disease reduction
    1. Dosing qid: 4% Peptic Ulcer Disease recurrence
    2. Dosing bid: 8% Peptic Ulcer Disease recurrence
    3. Placebo: 16% Peptic Ulcer Disease recurrence
    4. Reference
      1. Raskin (1995) Ann Intern Med 123:344

Misoprostol (C0085174)

Definition (MSH)A synthetic analog of natural prostaglandin E1. It produces a dose-related inhibition of gastric acid and pepsin secretion, and enhances mucosal resistance to injury. It is an effective anti-ulcer agent and also has oxytocic properties.
Definition (NCI)A radioprotective agent that belongs to the family of drugs called prostaglandins.
ConceptsEicosanoid (T111) , Pharmacologic Substance (T121)
EnglishMisoprostol, MISOPROSTOL PREPARATION, Misoprostol product
Spanishmisoprostol
CreditsDerived from the NIH UMLS (Unified Medical Language System)


Cytotec (C0591321)

ConceptsEicosanoid (T111) , Pharmacologic Substance (T121)
EnglishCytotec, Heumann Brand of Misoprostol, Misoprostol Heumann Brand, Misoprostol Pharmacia Brand, Misoprostol Searle Brand, Pharmacia Brand of Misoprostol, Pharmacia Spain Brand of Misoprostol, Searle Brand of Misoprostol
CreditsDerived from the NIH UMLS (Unified Medical Language System)



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