III. History: Allergy

  1. Early Onset of Allergic Rhinitis
  2. Positive Family History of Atopy
  3. Seasonal Allergic Rhinitis symptoms
  4. Provocative Symptoms
    1. Worse with animal exposure
    2. Worse outdoors
    3. Worse near cut grass
    4. Better in air conditioning
  5. Tobacco and chemicals are not the primary cause
  6. History of prior relief with Immunotherapy

IV. Prevention

  1. See Allergen Control (especially Dust mite exposure)
  2. Protocol in children with strong atopic family histories (2 first degree relatives)
    1. Exclusive Breast Feeding (preferred) or hydrolyzed formula for first year
    2. No solid foods until after 6 months of age
    3. Delay nuts, shellfish, and fish until over age 4 years
    4. Breast-feeding mother avoids eggs, milk, tree nuts, peanuts, and seafood
    5. Fiocchi (2006) Ann Allergy Asthma Immunol 97(1):10-20 [PubMed]

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Ontology: Atopy (C0392707)

Definition (CHV) an allergic reaction with strong family tendencies
Definition (NCI) A genetic predisposition to form IgE antibodies in response to exposure to allergens and therefore, for the development of immediate (type I) hypersensitivity and atopic conditions, such as allergic rhinitis; bronchial asthma, atopic dermatitis, and food allergy. Mutations of specific alleles on the long arm of chromosome 5 have been associated with higher levels of IL-4 and IgE and are known as IL-4 promoter polymorphisms.
Definition (CSP) genetic predisposition toward the development of immediate (type I) hypersensitivity reactions against common environmental antigens (atopic allergy); the most common clinical manifestation is allergic rhinitis; bronchial asthmas, atopic dermatitis and food allergy also occur.
Concepts Pathologic Function (T046)
SnomedCT 115665000, 55985003
Italian Atopia, Atopico
English Atopic allergy, Atopy, Atopic, atopic reactions, atopic allergy, allergies atopic, allergy atopic, atopic, atopy, atopic diathesis, Atopic reaction, Atopic state, Atopic diathesis, Atopic reaction (disorder), Atopy (disorder), Atopic reaction, NOS, Atopic Allergy
Dutch atopisch, atopie
French Atopique, Atopie
German atopisch, Atopie
Portuguese Atópico, Atopia
Spanish Atópico, atopia, atopia (trastorno), atopía (trastorno), atopía, diátesis atópica, estado atópico, reacción atópica (trastorno), reacción atópica, Atopía
Japanese アトピー, アトピー性, アトピーセイ, アトピー
Czech Atopie
Hungarian Atopia, Atopiás