Cardiovascular Medicine Book

Congestive Heart Failure

  • Nesiritide

Coronary Artery Disease

Electrocardiogram

Examination

Hyperlipidemia

Hypertension

Miscellaneous

Pericardial Disorders

Obstetrics Chapter related topics

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NesiritideAka: Natrecor, Recombinant Human Brain Natriuretic Peptide

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  1. Indications
    1. Decomensated Congestive Heart Failure
  2. Mechanism
    1. Recombinant Human Brain Natriuretic Peptide
    2. Results in venous and arterial vasodilation
  3. Dosing
    1. Bolus: 2 mcg/kg IV bolus
    2. Maintenance: 0.01 mcg/kg/min for 24-48 hours
  4. Efficacy
    1. Improves CHF symptoms
    2. Increases mortality within first 30 days
    3. Sackner-Bernstein (2005) JAMA 293:1900
  5. Cost
    1. Typical course is 2 vials at $530 per vial
  6. Monitoring
    1. Blood Pressure during administration (hypotension risk)
    2. Serum Creatinine

Brain natriuretic peptide (C0054015)

Definition (NCI)A recombinant version of the cardiac neurohormone, human B-type natriuretic peptide (hBNP) produced by the ventricular myocardium. Nesiritide binds to natriuretic peptide receptors on vascular smooth muscle and endothelial cells, through which it triggers guanylate cyclase dependent signal transduction resulting in increase of intracellular concentrations of cGMP. This leads to smooth muscle cell relaxation causing arterial and venous dilatation.
Definition (PDQ)A recombinant version of the cardiac neurohormone, human B-type natriuretic peptide (hBNP) produced by the ventricular myocardium. Nesiritide binds to natriuretic peptide receptors on vascular smooth muscle and endothelial cells, through which it triggers guanylate cyclase dependent signal transduction resulting in increase of intracellular concentrations of cGMP. This leads to smooth muscle cell relaxation causing arterial and venous dilatation. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=434520&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=434520&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C47636" NCI Thesaurus)
Definition (MSH)A PEPTIDE that is secreted by the BRAIN and the HEART ATRIA, stored mainly in cardiac ventricular MYOCARDIUM. It can cause NATRIURESIS; DIURESIS; VASODILATION; and inhibits secretion of RENIN and ALDOSTERONE. It improves heart function. It contains 32 AMINO ACIDS.
ConceptsAmino Acid, Peptide, or Protein (T116) , Pharmacologic Substance (T121) , Hormone (T125)
EnglishBNP 32, BNP Gene Product, Brain Natriuretic Peptide, Brain Natriuretic Peptide 32, Natriuretic Factor 32, Natriuretic Peptide B Type, Natriuretic Peptide Type B, nesiritide, NESIRITIDE PREPARATION, Type B Natriuretic Peptide
Spanishnesiritida, nesiritide, péptido natriurético cerebral, péptido natriurético humano tipo B, péptido natriurético tipo B, peptido natriuretico cerebral, peptido natriuretico humano tipo B, peptido natriuretico tipo B
CreditsDerived from the NIH UMLS (Unified Medical Language System)


Natrecor (C1170421)

ConceptsAmino Acid, Peptide, or Protein (T116) , Pharmacologic Substance (T121)
EnglishNatrecor
CreditsDerived from the NIH UMLS (Unified Medical Language System)



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