II. Indications
- Small Vessel Vasculitis
- Granulomatosis with Polyangiitis (previously known as Wegener's Granulomatosis) suspected (cANCA)
III. Mechanism
- Antibodies bind to cytoplasmic region of Neutrophils
IV. Labs
- Cytospin preparations of Neutrophils are permeabilized
- Binding of serum antibodies assessed as with ANA
V. Labs: Interpretation
VI. Associated Conditions
- C-ANCA or PR3-ANCA
- Granulomatosis with Polyangiitis (Very Strongly associated)
- Positive in 75-98% of patients with Wegener's
- Sensitivity drops to 30% during remission
- Crescentic Glomerulonephritis (moderately associated)
- Polyarteritis Nodosa (Weakly associated)
- Granulomatosis with Polyangiitis (Very Strongly associated)
- P-ANCA or MPO-ANCA
- Crescentic Glomerulonephritis (Strongly associated)
- Polyarteritis Nodosa (Moderately associated)
- Churg-StraussVasculitis (Moderately associated)
- Granulomatosis with Polyangiitis (Weakly associated)
- Henoch-Schonlein Purpura (Possibly associated)
- Temporal Arteritis (Possibly associated)
VII. References
- Gladman in Klippel (1997) Rheumatic Diseases p. 255-6
- Peng in Ruddy (2001) Kelley's Rheumatology, p. 161-72
- Callegari (1995) Postgrad Med, 97(4):65-74 [PubMed]
- Lane (2002) Am Fam Physician 65(6):1073-80 [PubMed]