Anticyclic Citrullinated Peptide Antibody

Aka: Anticyclic Citrullinated Peptide Antibody, Anti-cyclic Citrullinated Peptide Antibody

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II. Indications

  1. Rheumatoid Arthritis Diagnosis confirmation
    1. Rheumatoid Factor or Antinuclear Antibody positive
    2. May also predict prognosis and erosive disease likelihood
    3. Does not correlate to therapy response (not used for monitoring)

III. Mechanism

  1. Enzyme-linked Immunosorbent Assay (ELISA)

IV. Efficacy: Rheumatoid Arthritis Diagnosis

  1. Test Sensitivity: 67%
  2. Test Specificity: 95%
  3. Positive Likelihood Ratio (LR+): 12.46
  4. Negative Likelihood Ratio (LR-): 0.36

V. References

  1. Ali (2018) Am Fam Physician 98(3): 164-70 [PubMed]
  2. Barra (2011) Rheumatology 50(2): 311-6 [PubMed]
  3. Nishimura (2007) Ann Intern Med 146(11): &97-808 [PubMed]

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