II. Causes
- Untreated Acute Thiamine Deficiency (e.g. Alcoholism)
- See Acute Thiamine Deficiency for a full list of causes
III. Pathophysiology
- Follows Wernicke's Encephalopathy
- Lesions develop in mammillary bodies and Thalamus
IV. Signs
- Life-long neurologic Impairment with learning difficulties
- Severe Short Term Memory loss
- Intact Immediate Memory
- Confabulation
V. Management
VI. Prognosis
- Life-long Impairment
- Improvement in 75% of patients with treatment
VII. References
- Rendon et al. (2017) Crit Dec Emerg Med 31(6): 15-21