Zanamivir

Aka: Zanamivir, Relenza

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II. Indications: Neuraminidase Inhibitor

  1. Neuraminidase Inhibitors covers both Influenza A and Influenza B
  2. Influenza
  3. Influenza prophylaxis

III. Contraindications

  1. Asthma
  2. COPD

IV. Precautions

  1. See Oseltamivir

V. Dosing

  1. Contraindicated in bronchospastic disease
  2. Take the first 2 doses at least 2 hours apart (first day)
  3. Treatment (age 7 years and older)
    1. Dose: 10 mg (2 inhalations) twice daily for 5 days
  4. Prevention (age 5 years and older)
    1. Dose: 10 mg (1 inhalation) daily for 10 days

VI. Adverse effects

  1. Bronchospasm (with Relenza only)
  2. Neuropsychiatric effects
  3. Stevens-Johnson Syndrome (rare)

VII. Safety

  1. Considered safe in pregnancy
  2. Considered safe in Lactation

VIII. Resources

  1. Zanamivir (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=d7c3bcc3-0c0d-4068-fd80-88cf54a376ef
  2. CDC Influenza Antivirals summary
    1. http://www.cdc.gov/flu/professionals/antivirals/summary-clinicians.htm

IX. References

  1. (2014) Presc Lett 21(12): 70
  2. (2013) Med Lett Drugs Ther 11(127): 19-30 [PubMed]
  3. (2002) Pediatrics 110(6):1246-52 [PubMed]
  4. Stiver (2003) CMAJ 168(1):49-57 [PubMed]

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