II. Precautions
-
QT Prolongation with Levofloxacin (Levaquin)
- Three fold increased risk of Sudden Cardiac Death while on Levofloxacin
- This appears to be a class effect with most Fluoroquinolones except Ciprofloxacin
- Ray (2013) N Engl J Med 366(20): 1881-90 [PubMed]
III. Activity Spectrum
- Gram Negative Rod coverage (see other Fluoroquinolones)
- Atypical Bacteria
- Moderate Gram Positive activity
IV. Indications
- Community Acquired Pneumonia
- Refractory acute Bacterial Sinusitis (third line agent)
V. Preparations
- Levofloxacin (Levaquin)
- Moxifloxacin (Avelox)
- Low urine concentrations (avoid in UTI)
- No Pseudomonas coverage
- Highest risk Quinolone for QT Prolongation
- Sparfloxacin (Zagam)
- Low urine concentrations (avoid in UTI)
- Gatifloxacin (Tequin)
- Removed from U.S. market in 2006 due to fatalities (Hypoglycemia related)
VI. Adverse Effects
- See Fluoroquinolone
-
Hypoglycemia with Gatifloxacin (Tequin)
- Has occurred in non-diabetics
- Contraindicated in Diabetes Mellitus
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Related Studies
| levofloxacin (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| LEVOFLOXACIN 25 MG/ML SOLUTION | Generic | $0.98 per ml |
| LEVOFLOXACIN 250 MG TABLET | Generic | $0.14 each |
| LEVOFLOXACIN 500 MG TABLET | Generic | $0.17 each |
| LEVOFLOXACIN 750 MG TABLET | Generic | $0.31 each |
| gatifloxacin (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| GATIFLOXACIN 0.5% EYE DROPS | Generic | $10.81 per ml |
| moxifloxacin (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| MOXIFLOXACIN 0.5% EYE DROPS | Generic | $3.48 per ml |
| MOXIFLOXACIN HCL 400 MG TABLET | Generic | $1.38 each |