II. Indications
- Sulfadiazine Systemic
- Toxoplasmosis Prevention and Treatment
- Silver Sulfadiazine Topical Cream (Silvadene, SSD)
III. Contraindications
- Severe Renal Insufficiency
- Infants age <2 months old (risk of Kernicterus with systemic Sulfadiazine)
IV. Mechanism
- See Sulfonamide
V. Medications
- Sulfadiazine Systemic
- See Toxoplasmosis
- Use limited to Toxoplasmosis Prevention and management (combined with Pyrimethamine and leucovorin)
- Silver Sulfadiazine Topical Cream (Silvadene, SSD)
- Topical Cream used in Burn Injury
- See Burn Management
VI. Dosing
- Systemic Sulfadiazine
- See Toxoplasmosis
- Silver Sulfadiazine Topical (Silvadene Cream)
- See Burn Management
VII. Adverse Effects
- See Sulfadiazine
-
Crystalluria
- Sulfadiazine is more likely to precipitate in acidic urine
- Maintain oral hydration
- Reduce dose in Renal Insufficiency
VIII. Drug Interactions
-
Warfarin
- Increases INR
- Increases drug levels of other medications
IX. Resources
- Sulfadiazine (DailyMed)
- Silver Sulfadiazine (DailyMed)
Images: Related links to external sites (from Bing)
Related Studies
| silver sulfadiazine (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| SILVER SULFADIAZINE 1% CREAM | Generic | $0.25 per gram |