II. Activity Spectrum (See Class I and Class II below)

  1. Gram Negative Rod coverage (see other Fluoroquinolones)
  2. Some atypical Bacteria coverage (Class II only)
  3. See Ciprofloxacin below for other activity

III. Preparations: Class I

  1. Indications
    1. Uncomplicated Urinary Tract Infections
  2. Similar spectrum to first generation agents
    1. Improved Gram Negative coverage over first generation
    2. Low systemic drug concentrations
  3. Agents
    1. Lomefloxacin (Maxaquin)
    2. Enoxacin (Penetrex)
    3. Norfloxacin (Noroxin)

IV. Preparations: Class II

  1. Indications
    1. Complicated Urinary Tract Infections
    2. Specific types of Bacterial Gastroenteritis
    3. Prostatitis
    4. Sexually Transmitted Disease
    5. Avoid in Community Acquired Pneumonia
      1. Risk of pneumococcal bacteremia and Meningitis
  2. Additional Indications for Ciprofloxacin
    1. Pseudomonas aeruginosa
    2. Bacillus anthracis or Anthrax (first line agent)
    3. Vibrio Cholerae (Norfloxacin also covers)
    4. Yersinia pestis or Plague (first line agent)
    5. Tularemia (alternative medication)
  3. Significantly more active than Class I agents
    1. Broader Gram Negative coverage than Class I agents
    2. High systemic drug concentrations
    3. Some atypical Bacteria coverage
    4. Pseudomonas aeruginosa (Ciprofloxacin only)
  4. Agents
    1. Ciprofloxacin (Cipro)
    2. Ofloxacin (Floxin)

V. Directions

  1. Take on an empty Stomach
  2. Take more than 1 hour before or two hours after food

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Cost: Medications

ciprofloxacin (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
CIPROFLOXACIN 0.2% OTIC SOLN Generic $6.34 each
CIPROFLOXACIN 0.3% EYE DROP Generic $1.74 per ml
CIPROFLOXACIN HCL 250 MG TAB Generic $0.10 each
CIPROFLOXACIN HCL 500 MG TAB Generic $0.15 each
CIPROFLOXACIN HCL 750 MG TAB Generic $0.21 each
ofloxacin (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
OFLOXACIN 0.3% EAR DROPS Generic $1.89 per ml
OFLOXACIN 0.3% EYE DROPS Generic $1.69 per ml