II. Indications
- Onchocerciasis (age 12 years and older)
III. Mechanism
- Avermectin antiparasitic and antihelminth agent similar to Ivermectin
- Greater use in veterinary rather than human medicine (beyond its indication for Onchocerciasis)
IV. Medications
- Tablets: 2 mg
V. Dosing: Adults (and Children age >12 years old)
- Take 8 mg (four tablets) orally for one dose
- Drug levels persist for months after dose
VI. Pharmacokinetics
- Half-Life: 23 days
VII. Safety
- Unknown safety in pregnancy
- Unknown safety in Lactation
VIII. Adverse Effects: General
- Orthostatic Hypotension
- Encephalopathy
- Occurs with coinfection with Loa loa
- Evaluate for Loa loa prior to treatment
- Onchodermatitis exacerbation
- Associated with hyperreactive Onchodermatitis (Sowda)
IX. Adverse Effects: Mazzotti Reaction (Immunologic Reaction in Onchocerciasis to Parasite Death)
- Nausea
- Fever
- Headache
- Arthralgias
- Urticaria
- Ophthalmic complications
X. Resources
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
- Moxidectin Tablets (DailyMed)