Imipenem-Cilastin Relebactam

Aka: Imipenem-Cilastin Relebactam, Recarbio

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II. Indications

  1. See Carbapenem
  2. Indicated in complicated UTI or intra-abdominal infections where other options have been exhausted

III. Mechanism

  1. See Carbapenem
  2. Recarbio is a combination of Imipenem-Cilastin with Relebactam

IV. Dosing: Adults

  1. CrCl >=90 ml/min
    1. Give 1.25 g IV every 6 hours administered over 30 minutes
  2. CrCl 60 to 89 ml/min
    1. Give 1 g IV every 6 hours administered over 30 minutes
  3. CrCl 30 to 59 ml/min
    1. Give 0.75 g IV every 6 hours administered over 30 minutes
  4. CrCl 15 to 29 ml/min
    1. Give 0.5 g IV every 6 hours administered over 30 minutes
  5. CrCl <15 ml/min
    1. Avoid unless Hemodialysis planned for within 48 hours
    2. Administer after Hemodialysis

V. Drug Interactions

  1. See Carbapenem

VI. Adverse Effects

  1. See Carbapenem

VII. Safety

  1. Unknown safety in pregnancy
  2. Unknown safety in Lactation

VIII. Resources

  1. Imipenem-Cilastin Relebactam (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=be32f468-738b-40df-a425-591e12f65159

IX. References

  1. LiverTox (2017), accessed online 1/2/2023
    1. https://www.ncbi.nlm.nih.gov/books/NBK548705/
  2. Hamilton (2020) Tarascon Pharmacopeia
  3. (2012) Presc Lett, Resource #231205, Comparison of Carbapenem Antibiotics
  4. Zhanel (2007) Drugs: 67(7): 1027-52 [PubMed]

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