II. Indications
- See Carbapenem
- Avoid in Pseudomonas and Acinetobacter infections (inactive)
- Complicated Infections
- Community Acquired Pneumonia (limited activity)
- Diabetic Foot Infections
- Acute Intraabdominal and Pelvis Infections
- Complicated Skin and Soft Tissue Infections
- Complicated Urinary Tract Infections
III. Mechanism
- See Carbapenem
IV. Dosing
- Administration
- Administer IV doses over 30 minutes (and do not combine with dextrose solutions)
- Dilute IM doses with Lidocaine (if not allergic)
- FDA approved duration up to 14 days IV and up to 7 days IM
- Adult (and age >12 years)
- Standard Dose: 1 g IM/IV every 24 hours (or 1 hour prior to surgical incision)
- Renal Dosing
- CrCl <30 ml/min: 500 mg IV every 24 hours
- Hemodialysis: 500 mg IV every 24 hours
- Child (3 months to 12 years)
- Dose: 15 mg/kg IV or IM every 12 hours (max total daily dose: 1 gram/day)
V. Drug Interactions
- See Carbapenem
VI. Adverse Effects
- See Carbapenem
VII. Safety
- Unknown safety in pregnancy
- Safe in Lactation
VIII. Resources
IX. References
- LiverTox (2017), accessed online 1/2/2023
- Hamilton (2020) Tarascon Pharmacopeia
- (2012) Presc Lett, Resource #231205, Comparison of Carbapenem Antibiotics
- Zhanel (2007) Drugs: 67(7): 1027-52 [PubMed]
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Related Studies
| ertapenem (on 6/21/2023 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| ERTAPENEM 1 GRAM VIAL | Generic | $42.39 each |