II. Indications
III. Contraindications
- Staphylococcus aureus infection (poor activity)
IV. Mechanism
V. Medications
- Capsules: 400 mg
- Chewable Tablets: 100 or 200 mg (contain Phenylalanine)
- Suspension: 100 or 200 mg/5ml and 500 mg/5 ml
- Stable at room Temperature for 2 weeks
VI. Dosing
- Adult (or child age >13 years, weight > 45 to 50 kg)
- Standard Dosing
- Take 400 mg orally divided once daily
- Gonorrhea
- Take 400 mg orally for single dose
- Standard Dosing
- Child (age <13 years or weight < 45 to 50 kg)
- Standard Dosing
- Give 8 mg/kg/day divided daily to twice daily
- Febrile Urinary Tract Infection
- Give 16 mg/kg orally on day 1, then 8 mg/kg/day daily for 14 days
- Standard Dosing
-
Renal Dosing
- eGFR 21 to 60 ml/min (or Hemodialysis): Decrease usual dose to 75%
- eGFR <20 ml/min (or Peritoneal Dialysis): Decrease usual dose to 50%
VII. Safety
- Pregnancy Category B
- Safe in Lactation
VIII. Drug Interactions
-
Warfarin
- Cefixime may increase INR
-
Carbamazepine
- Cefixime may increase Carbamazepine levels
IX. Resources
X. References
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
- (2012) Presc Lett, Resource #280706, Comparison of Cephalosporins
Images: Related links to external sites (from Bing)
Related Studies
| cefixime (on 2/22/2023 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| CEFIXIME 200 MG/5 ML SUSP | Generic | $4.86 per ml |
| CEFIXIME 400 MG CAPSULE | Generic | $10.76 each |