Enoxaparin

Aka: Enoxaparin, Lovenox

advertisement

II. Indications

  1. Venous Thromboembolism (DVT, PE) prophylaxis and treatment
  2. Acute Coronary Syndrome

III. Mechanism

  1. See Low Molecular Weight Heparin (LMWH)

IV. Dosing: Prophylactic Dose

  1. Creatinine Clearance (CrCl) >30 ml/min AND Weight 40-150 kg
    1. Enoxaparin (Lovenox) 40 mg SQ daily for medical inpatients or abdominal surgery
    2. Enoxaparin (Lovenox) 30 mg SQ every 12 hours if s/p knee or hip replacement
  2. Creatinine Clearance (CrCl) >30 ml/min AND Weight >150 kg (or BMI 40 of higher)
    1. Enoxaparin (Lovenox) 40 mg SQ twice daily
  3. Creatinine Clearance (CrCl) 15-30 ml/min (or weight <40 kg)
    1. Enoxaparin (Lovenox) 30 mg SQ daily
  4. Creatinine Clearance (CrCl) <15 ml/min
    1. Enoxaparin (Lovenox) is contraindicated
    2. Use unfractionated heaprin 5000 units SQ every 8-12 hours

V. Dosing: Therapeutic Dose

  1. Creatinine Clearance (CrCl) >30 ml/min
    1. Enoxaparin (Lovenox) 1 mg/kg SQ every 12 hours OR
    2. Enoxaparin (Lovenox) 1.5 mg/kg SQ every 24 hours for inpatients with acute VTE (DVT, PE)
  2. Creatinine Clearance (CrCl) 15-30 ml/min (or weight <40 kg)
    1. Unfractionated Heparin is preferred
    2. As an alternative, Enoxaparin (Lovenox) 1 mg/kg SQ once daily for up to 7 days
  3. Creatinine Clearance (CrCl) <15 ml/min
    1. Enoxaparin (Lovenox) is contraindicated
    2. Use Unfractionated Heparin 5000 units SQ every 8-12 hours

VI. Safety

  1. Use in pregnancy when benefit outweighs the risk
  2. Considered safe in Lactation

VII. Efficacy

  1. See Low Molecular Weight Heparin (LMWH)

VIII. Resources

  1. Enoxaparin (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=61df24ff-c141-4353-9f2c-1af7af24f6b2

IX. References

  1. Dummer (2009) Perioperative Guidelines
  2. Douketis (2008) Chest 133(6 Suppl):299S-339S [PubMed]

Images: Related links to external sites (from Bing)

These images are a random sampling from a Bing search on the term "Enoxaparin." Click on the image (or right click) to open the source website in a new browser window. Search Bing for all related images

Related Studies

Cost: Medications

enoxaparin (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
ENOXAPARIN 100 MG/ML SYRINGE Generic $10.14 per ml
ENOXAPARIN 120 MG/0.8 ML SYR Generic $17.75 per ml
ENOXAPARIN 150 MG/ML SYRINGE Generic $16.75 per ml
ENOXAPARIN 30 MG/0.3 ML SYR Generic $12.43 per ml
ENOXAPARIN 300 MG/3 ML VIAL Generic $13.43 per ml
ENOXAPARIN 40 MG/0.4 ML SYR Generic $12.12 per ml
ENOXAPARIN 60 MG/0.6 ML SYR Generic $10.70 per ml
ENOXAPARIN 80 MG/0.8 ML SYR Generic $10.14 per ml
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. GoodRx is another tool for finding lower drug prices.

Related Topics in Pharmacology

advertisement