II. Contraindications

  1. HLA-B*5701 positive state (screen in advance of starting)
    1. Associated with life-threatening Hypersensitivity

IV. Dosing

  1. Abacavir 300 mg PO bid

V. Precautions

  1. Do not use unless patient is negative for HLA-B5701
    1. Risk of Hypersensitivity Reaction if HLA-B5701 positive
    2. Lucas (2007) J Antimicrob Chemother 59(4):591-3 +PMID:17317695 [PubMed]

VI. Adverse Effects

  1. Hypersensitivity (3%)
    1. Presents with Fever and Rash
    2. Associated with HLA-B*5701 positive state
    3. Mean onset 11 days after start
    4. Lethal reaction if restarted after reaction (50%)
    5. Never rechallenge Abacavir after reaction
  2. Cardiovascular risk
    1. Unclear association is being investigated

VII. Resources: Abacavir Hypersensitivity Registry

  1. Phone: 1-800-270-0425

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Related Studies

Cost: Medications

abacavir (on 11/23/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
ABACAVIR 300 MG TABLET Generic $0.61 each
ABACAVIR-LAMIVUDINE 600-300 MG Generic $2.58 each