II. Contraindications
- HLA-B*5701 positive state (screen in advance of starting)
- Associated with life-threatening Hypersensitivity
III. Mechanism
IV. Dosing
- Abacavir 300 mg PO bid
V. Precautions
- Do not use unless patient is negative for HLA-B5701
- Risk of Hypersensitivity Reaction if HLA-B5701 positive
- Lucas (2007) J Antimicrob Chemother 59(4):591-3 +PMID:17317695 [PubMed]
VI. Adverse Effects
-
Hypersensitivity (3%)
- Presents with Fever and Rash
- Associated with HLA-B*5701 positive state
- Mean onset 11 days after start
- Lethal reaction if restarted after reaction (50%)
- Never rechallenge Abacavir after reaction
- Cardiovascular risk
- Unclear association is being investigated
VII. Resources: Abacavir Hypersensitivity Registry
- Phone: 1-800-270-0425
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Related Studies
| abacavir (on 11/23/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| ABACAVIR 300 MG TABLET | Generic | $0.61 each |
| ABACAVIR-LAMIVUDINE 600-300 MG | Generic | $2.58 each |