II. Indications
- Functional Constipation
- Colonoscopy Preparation
III. Contraindications
IV. Mechanism
- Magnesium salt Osmotic Laxatives
- Poorly absorbed, hyperosmolar agents
V. Precautions
- Avoid longterm use due to Electrolyte loss risk
- These agents are typically used once as part of a bowel regimen
VI. Dosing
-
General
- Patients should have immediate access to toilet for at least 6 hours after taking Magnesium Citrate
- Adult (and age >12 years)
- Full dose: Take 8 to 10 ounces (240 to 300 ml, 1 bottle) orally divided once or twice for 1 day
- Half dose: Take 5 oz (150 ml, 1/2 bottle) orally once
- Child (age 2 to 12 years)
- Age 2 to 5 years: 1 to 3 ml/kg/day divided once or twice for 1 day
- Age 6 to 11 years: 4 ml/kg (up to 200 ml) OR 100 to 150 ml divided once or twice for 1 day
VII. Pharmacokinetics
- Absorption of up to 30% of Magnesium Citrate dose
- Rapid onset within 3 hours
- Patients should have immediate access to toilet for at least 6 hours after taking Magnesium Citrate
VIII. Adverse Effects
- Hypermagnesemia (in patients with Renal Failure)
IX. Safety
- Pregnancy Category B
- Unknown Safety in Lactation
X. Drug Interactions
- Decreases absorption of other drugs
-
CNS Depressants
- Magnesium Citrate may have additive effects with increased CNS depression
XI. Resources
- Magnesium Citrate (DailyMed)
XII. References
- (2023) Management of Constipation, Presc Lett, #390108
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
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Related Studies
| magnesium citrate (on 9/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| MAGNESIUM CITRATE SOLUTION | Generic OTC | $0.01 per ml |