Maddrey Discriminant Function

Aka: Maddrey Discriminant Function

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II. Indications

  1. Acute Alcoholic Hepatitis Prognosis

III. Calculation

  1. Discriminant function = 4.6 x (PTa - PTc) + Bili
  2. Where
    1. PTa: Actual ProTime (PT) in seconds
    2. PTc: Normal ProTime (PT) in seconds (typically 11-13 s)
    3. Bili: Serum Bilirubin in mg/dl

IV. Interpretation

  1. Discriminant result >32 is associated with severe disease and a 1 month mortality >50%

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