Gigantism

Aka: Gigantism

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II. Pathophysiology

  1. Eosinophilic Pituitary Adenoma
    1. Results in hypersecretion of Growth Hormone
    2. Contrast with Cerebral Gigantism (Sotos Syndrome) which is a genetic disorder
  2. Occurs in children before epiphyseal closure
    1. Results in excessive growth
    2. Contrast with Acromegaly in adults (after epiphyseal closure)

III. Symptoms

  1. Rapid excessive growth
  2. Weakness

IV. Signs

  1. Tall Stature
    1. Excessive lengthening of bones
    2. Normal body proportions
  2. Increased Intracranial Pressure
  3. Diffuse organ hyperplasia

V. Imaging

  1. XRay Sinuses
    1. Frontal Sinuses enlarged
  2. XRay Hand
    1. Tufting of distal phalanges
    2. Metacarpal broadening
  3. XRay Spine
    1. Vertebral broadening
  4. XRay Mandible
    1. Hyperplasia of the Mandible
  5. CT Head
    1. Sella turcica widening

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