Sublingual Immunotherapy

Aka: Sublingual Immunotherapy, Grastek, Oralair, Ragwitek, Odactra

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II. Indications

  1. Allergy Immunotherapy
    1. For allergic symptoms refractory to standard allergy medications

III. Precautions

  1. Not to be used without formal Allergy Testing first
  2. Observe in office for first sublingual dose
  3. All patients should receive Epinephrine auto-injector in case of Anaphylaxis reaction

IV. Preparations

  1. Grass allergies
    1. Timothy Grass Pollen cross reacts with 6 other grass pollens (Grastek)
    2. Five Grass Pollen Extract (Oralair)
  2. Ragweed allergy
    1. Short Ragweed pollent extract (Ragwitek)
  3. Dust mites
    1. House Dust mite Allergen Extract (Odactra)
  4. Peanut Allergy
    1. Peanut Allergen Oral Powder (Palforzia)

V. Dosing: Protocol

  1. Start medication 3-4 months prior to allergy season and continue throughout the season
  2. Have Epinephrine auto-injector readily available in case of Anaphylaxis reaction

VI. Advantages

  1. More convenient, possibly safer, and without the pain of standard allergy Immunotherapy injections
  2. Efficacy approaches that of standard allergy Immunotherapy injections

VII. Disadvantages

  1. More expensive than standard allergy Immunotherapy injections

VIII. References

  1. (2014) Presc Lett 21(6):35
  2. Koberlein (2013) Immunotherapy 5(1):13-21 [PubMed]
  3. Maloney (2014) Ann Allergy Asthma Immunol 112(2):146-153 [PubMed]
  4. Nolte (2013) Ann Allergy Asthma Immunol 110(6):450-456 [PubMed]

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Related Studies

Cost: Medications

odactra (on 9/20/2023 at Medicaid.Gov Survey of pharmacy drug pricing)
ODACTRA 12 SQ-HDM SL TABLET $11.03 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. GoodRx is another tool for finding lower drug prices.

Related Topics in Pharmacology

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