II. Indications
III. Mechanism
- See Antihistamine
- H1 Receptor Antagonist
- Clemastine is an Ethanolamine First Generation Antihistamine with strong Anticholinergic activity
IV. Precautions
- Although FDA approved for children, FDA does not recommend routine Antihistamine use age <4 years
- Deaths have occurred in younger children related to Anticholinergic Toxicity
V. Medications
- Clemastine Fumarate (tablets) at 1.34 mg are equivalent to Clemastine base 1 mg
VI. Dosing: Allergic Rhinitis
- Adult (age >=12 years): 1.34 mg orally twice daily (maximum 8.04 mg/day)
- Child (age 6 to 11 years): 0.67 mg orally twice daily (maximum 4.02 mg/day)
VII. Dosing: Urticaria or Angioedema
- Adult (age >=12 years): 2.68 mg orally two to three times daily (maximum 8.04 mg/day)
- Child (age 6 to 11 years): 1.34 mg orally twice daily (maximum 4.02 mg/day)
VIII. Adverse Effects
- See Antihistamine
- See Anticholinergic Toxicity
- Sedation
IX. Safety
- Pregnancy category B
- Avoid in Lactation
X. Resources
XI. References
- Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 146-7
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
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Related Studies
| clemastine (on 6/21/2023 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| CLEMASTINE FUM 2.68 MG TAB | Generic | $0.61 each |