II. Indications
- See Loop Diuretic
III. Contraindications
- Povidone Hypersensitivity
- Anuria
- Hepatic coma
IV. Mechanism
- See Loop Diuretic
V. Background
- Well Absorbed
- Oral Bioavailability 80-90% consistently, even in severe edema (contrast with Furosemide)
- Once daily dosing (contrast with all other Loop Diuretics)
- Half-Life: 3 to 4 hours (doubled in hepatic dysfunction)
VI. Dosing: Adults
- Oral
- Start: 10-20 mg orally daily
- Titrate as needed by doubling dose
- Maximum: 200 mg/day (40 mg in Chronic Renal Failure)
- Duration: 12-16 hours
- Onset: 1 hour
- Intravenous Dosing (adults)
- Start: 10 mg IV
- Maximum: 100-200 mg/day
- Intravenous Infusion (adults)
- Load: 20 mg
- Rate: 5-20 mg/hour
VII. Adverse Effects
- See Loop Diuretic
VIII. Safety
- Pregnancy Category B
- No safety information available for use in pregnancy
- Unknown Safety in Lactation
IX. Drug Interactions
- Avoid with NSAIDs
- Metabolized by CYP2C9
- Avoid with potent CYP2C9 Inhibitors (decrease Torsemide clearance)
- Increases levels of other drugs
X. Resources
- Torsemide Tablet (DailyMed)
XI. References
- (2021) Presc Lett, Resource #370507, Commonly Used Diuretics
- (2020) Med Lett Drugs Ther 62(1598): 73-80
- Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 62-3
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
Images: Related links to external sites (from Bing)
Related Studies
| torsemide (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| TORSEMIDE 10 MG TABLET | Generic | $0.08 each |
| TORSEMIDE 100 MG TABLET | Generic | $0.23 each |
| TORSEMIDE 20 MG TABLET | Generic | $0.08 each |
| TORSEMIDE 5 MG TABLET | Generic | $0.07 each |