II. Indications
- See ACE Inhibitor
III. Mechanism
- See ACE Inhibitor
- Non-sulfhydryl Angiotensin Converting Enzyme (ACE) inhibitor
- Trandolapril is a prodrug, converted to its active form Trandolaprilat in the liver via de-esterification
IV. Dosing: Adults
- Adequate 24 hour Blood Pressure control may require twice daily dosing
-
Hypertension
- Start 1 mg orally daily or divided twice daily
- Start 0.5 mg/day in renal dysfunction or comorbid Diuretic use
- Target 2 to 4 mg orally daily
- Start 1 mg orally daily or divided twice daily
-
Congestive Heart Failure (CHF) or post-Myocardial Infarction
- Start 0.5 to 1 mg orally daily
- Titrate to target 4 mg orally daily
- Maximum: 8 mg/day (but no benefit above 4 mg/day)
V. Supplied
- Available as generic scored tablet (1 mg) and unscored tablet (2 and 4 mg)
VI. Metabolism
- Excretion 66% hepatic and 33% renal
VII. Adverse Effects
- See ACE Inhibitor
VIII. Safety
- See ACE Inhibitor
- Pregnancy Category X
- Avoid in Lactation
IX. Resources
- Trandolapril (DailyMed)
X. References
- (2016) Presc Lett, Resource #321151, ACE Inhibitor Antihypertensive Dose Comparison
- (2020) Med Lett Drugs Ther 62(1598): 73-80
- Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 68-9
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
Images: Related links to external sites (from Bing)
Related Studies
| trandolapril (on 4/20/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| TRANDOLAPRIL 1 MG TABLET | Generic | $0.21 each |
| TRANDOLAPRIL 2 MG TABLET | Generic | $0.17 each |
| TRANDOLAPRIL 4 MG TABLET | Generic | $0.24 each |