II. Indications
- See ACE Inhibitor
III. Mechanism
- See ACE Inhibitor
- Non-sulfhydryl Angiotensin Converting Enzyme (ACE) inhibitor
- Quinapril is a prodrug, converted to its active form Quinaprilat via hydrolysis
IV. Dosing
- Adequate 24 hour Blood Pressure control may require twice daily dosing
-
Hypertension
- Start 10 mg orally daily
- Start 2.5 to 5 mg orally daily in renal dysfunction or recurrent Diuretic use
- Target 20 to 40 mg/day
- Start 10 mg orally daily
-
Congestive Heart Failure (CHF)
- Start: 5 mg/day divided once to twice daily
- Titrate weekly to target 20 to 40 mg/day divided once to twice daily
- Low dose is especially important if concurrent Diuretic use
-
Renal Dosing
- GFR 30-60
- Start 5 mg orally daily
- GFR 10-30
- Start 2.5 mg orally daily
- GFR 30-60
- Maximum: 80 mg/day (no benefit above 40 mg/day)
V. Metabolism
- Excretion is 50-60% renal
VI. Supplied
- Available as generic scored tablets (5 mg) and unscored tablets (10,20 and 40 mg)
VII. Adverse Effects
- See ACE Inhibitor
VIII. Safety
- See ACE Inhibitor
- Pregnancy Category X
- Avoid in Lactation
IX. Resources
X. References
- (2016) Presc Lett, Resource #321151, ACE Inhibitor Antihypertensive Dose Comparison
- (2020) Med Lett Drugs Ther 62(1598): 73-80
- Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 68-9
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
Images: Related links to external sites (from Bing)
Related Studies
| quinapril (on 2/23/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| QUINAPRIL 10 MG TABLET | Generic | $0.07 each |
| QUINAPRIL 20 MG TABLET | Generic | $0.09 each |
| QUINAPRIL 40 MG TABLET | Generic | $0.11 each |
| QUINAPRIL 5 MG TABLET | Generic | $0.08 each |
| QUINAPRIL-HYDROCHLOROTHIAZIDE 10-12.5 MG TAB | Generic | $0.31 each |
| QUINAPRIL-HYDROCHLOROTHIAZIDE 20-12.5 MG TAB | Generic | $0.36 each |
| QUINAPRIL-HYDROCHLOROTHIAZIDE 20-25 MG TAB | Generic | $0.34 each |