II. Indications
- See ACE Inhibitor
III. Mechanism
- See ACE Inhibitor
- Non-sulfhydryl Angiotensin Converting Enzyme (ACE) inhibitor
- Perindopril is a prodrug, converted to its active form Perindoprilat via hydrolysis
IV. Dosing
- Adequate 24 hour Blood Pressure control may require twice daily dosing
-
Hypertension
- Start 4 mg orally daily or divided twice daily
- Start at 2 mg/day in renal dysfunction or concurrent Diuretic use
- Target 4 to 8 mg/day
- Start 4 mg orally daily or divided twice daily
-
Coronary Artery Disease secondary prevention
- Start 4 mg orally daily for 2 weeks
- May increase after 2 weeks to 8 mg/day
-
Congestive Heart Failure (not FDA approved)
- Start 2 mg orally daily
- Maximum 16 mg/day
- Maximum 16 mg/day
V. Supplied
- Available as generic unscored tablets (2, 4, 8 mg)
VI. Metabolism
- Primarily renal metabolism
VII. Adverse Effects
- See ACE Inhibitor
VIII. Safety
- See ACE Inhibitor
- Pregnancy Category X
- Avoid in Lactation
IX. Resources
X. References
- (2016) Presc Lett, Resource #321151, ACE Inhibitor Antihypertensive Dose Comparison
- (2020) Med Lett Drugs Ther 62(1598): 73-80
- Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 68-9
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
Images: Related links to external sites (from Bing)
Related Studies
| perindopril (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| PERINDOPRIL ERBUMINE 4 MG TAB | Generic | $0.47 each |
| PERINDOPRIL ERBUMINE 8 MG TAB | Generic | $0.50 each |