Isradipine

Aka: Isradipine, Dynacirc

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II. Indications

  1. Hypertension

III. Dosing: Adults

  1. Start 2.5 mg orally twice daily
  2. Target: 5 to 10 mg/day divided twice daily
  3. Maximum: 20 mg/day (10 mg/day in the elderly)

IV. Mechanism

  1. See Dihydropyridine Calcium Channel Blocker
  2. Selectively inhibits vascular smooth Muscle Contraction and SA Node conduction
  3. Does not reduce cardiac contractility
  4. Does not affect AV Node conduction

V. Adverse Effects

  1. See Dihydropyridine Calcium Channel Blocker
  2. Less reflex Tachycardia than other agents due to selectivity
  3. Headache
  4. Peripheral Edema
  5. Flushing

VI. Safety

  1. Pregnancy Category C
  2. Unknown Safety in Lactation

VII. Metabolism

  1. Well absorbed, but high first pass metabolism

VIII. Resources

  1. Isradipine Capsule (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=bf3425e0-428d-4bdb-ac9a-3b9d483df83a

IX. References

  1. (2022) Presc Lett, Resource #381108, Comparison of Calcium Channel Blockers
  2. (2020) Med Lett Drugs Ther 62(1598): 73-80
  3. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 70-1
  4. Hamilton (2020) Tarascon Pocket Pharmacopoeia

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