II. Indications
-
Hypertension
- Weak Diuretics primarily used to counter urinary Potassium loss with other Diuretics
- Often combined with Thiazide Diuretics and rarely used alone
III. Contraindications
- Significant Renal Insufficiency
- Anuria
- Hyperkalemia
IV. Mechanism
- Potassium-Sparing Diuretics only (Aldosterone independent)
- Primarily used to counter urinary Potassium loss with other Diuretics (e.g. Thiazide Diuretics)
- Act directly at the distal convoluted tubule (Aldosterone independent)
V. Pharmacokinetics
- Renal excretion (unchanged in urine)
- Half-Life: 6 hours
- Onset: 2 hours
- Duration: 24 hours
VI. Dosing
- Dose: 5 mg orally daily
- Maximum: 20 mg/day
VII. Adverse Effects
VIII. Safety
- Pregnancy Category B
- Unknown Safety in Lactation
IX. Resources
X. References
- (2021) Presc Lett, Resource #370507, Commonly Used Diuretics
- (2020) Med Lett Drugs Ther 62(1598): 73-80
- Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 62-3
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
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