II. Epidemiology

  1. Occurs in uncircumsized men over age 60 years

III. Causes

  1. Genital Warts due to HPV infection (key causative factor)
  2. Local Trauma from heat, friction or inflammation

IV. Symptoms

  1. Asymptomatic in 50% of men (other than the lesions being present)
  2. Pain
  3. Pruritus

V. Signs

  1. Velvet-like Plaques on glans penis (erythroplasia of Queyrat)
    1. Raised, beefy red irregularly shaped Plaques
      1. May be crusted, non-red lesions in uncircumsized patients
    2. Ulceration may occur
    3. Range in size from 0.2 cm up to 3.5 cm
    4. Distributed on the glans penis, Urethral meatus, coronal sulcus and foreskin
  2. Keratotic Plaques (Bowen Disease)
    1. Occur on penile shaft, scrotal skin, perineum

VI. Labs: Biopsy

  1. Biopsy all suspicious lesions

VII. Management

  1. Surgery
    1. Mohs Micrographic Surgery
    2. Circumcision if the lesion is isolated to the foreskin
  2. Topical agents have been used with varying success (5-FU, curettage, laser ablation, Aldara)
    1. Most topical treatments are associated with recurrence
  3. Radiation Therapy
    1. Consider in non-surgical candidates

VIII. Differential Diagnosis

IX. Complications

  1. Progresses to invasive Penile Squamous Cell Carcinoma in 5-30% of patients

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Ontology: Carcinoma in situ of penis (C0154089)

Definition (NCI_NCI-GLOSS) Abnormal cells are found on the surface of the skin of the penis. These abnormal cells may become cancer and spread into nearby normal tissue.
Definition (NCI) Stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ. cN0: No palpable or visibly enlarged inguinal lymph nodes. pN0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)
Concepts Neoplastic Process (T191)
ICD9 233.5
ICD10 D07.4 , M8080/2, D00-D09
SnomedCT 18348002, 398768004, 398831006, 255104003, 189208007, 255105002, 255147003, 92679008, 400092004
English Penis, Carcinoma in situ of penis, CIS - Carc in situ of penis, [M]Queyrat's erythroplasia, Bowen Disease of the Penis, Queyrat erythroplasia of penis (diagnosis), carcinoma in situ of penis, carcinoma in situ of penis (diagnosis), Queyrat erythroplasia of penis, Bowen's disease of penis (diagnosis), Penis carcinoma in situ, Ca in situ penis, Queyrat erythroplasia, Bowen disease of penis, Erythroplasia of Queyrat NOS, erythroplasia queyrat, erythroplasia of queyrat, Penile Carcinoma In Situ AJCC v7, Queyrats's erythroplasia, stage 0 penile carcinoma in situ, Penile intraepithelial neoplasia grade III (diagnosis), Queyrat's erythroplasia, Bowen's disease of glans penis, Bowen's disease of penis, CIS - Carcinoma in situ of penis, Erythroplasia of Queyrat, Bowen's disease of penis (disorder), Carcinoma in situ of penis (disorder), Penile intraepithelial neoplasia grade III (disorder), Penile intraepithelial neoplasia grade III, Queyrat's erythroplasia (disorder), Queyrat's erythroplasia (morphologic abnormality), Carcinoma in situ of penis, NOS, Grade III Penile Intraepithelial Neoplasia, Grade III Squamous Intraepithelial Lesion of Penis, Grade III Squamous Intraepithelial Lesion of the Penis, Queyrat Erythroplasia, Queyrat's Erythroplasia, Bowen's Disease of Penis, Bowen's Disease of the Penis, Carcinoma in situ of Penis, Carcinoma in situ of the Penis, Penile Carcinoma In Situ
Italian Carcinomi in situ del pene, Eritroplasia di Queyrat, Carcinoma in situ del pene
Dutch peniscarcinoom in situ, Carcinoma in situ van penis, Queyrat erytroplasie, carcinoom in situ van de penis
German Peniskarzinom in situ, Carcinoma in situ: Penis, Carcinoma im situ des Penis, Queyrat Erythroplasie
Spanish Carcinoma de pene in situ, enfermedad de Bowen de glande, neoplasia intraepitelial de pene, grado III, neoplasia intraepitelial peniana grado III (trastorno), neoplasia intraepitelial de pene, grado III (trastorno), neoplasia intraepitelial peniana grado III, (M)eritroplasia de Queyrat, carcinoma in situ del pene (trastorno), carcinoma in situ del pene, carcinoma peniano in situ, enfermedad de Bowen de pene (trastorno), enfermedad de Bowen de pene, eritroplasia de Queyrat (anomalía morfológica), eritroplasia de Queyrat (trastorno), eritroplasia de Queyrat, Carcinoma in situ de pene, Eritroplasia de Queyrat
Japanese 陰茎上皮内癌, ケーラー紅色肥厚症, インケイジョウヒナイガン, ケーラーコウショクヒコウショウ
Czech Karcinom in situ penisu, Queyratova erytroplazie
Korean 음경의 상피내 암종
Hungarian Penis carcinoma in situ, Hímvessző in situ carcinomája, Queyrat erythroplasia
Portuguese Eritroplasia de Queyrat, Carcinoma do pénis in situ
French Carcinome in situ du pénis, Erythroplasie de Queyrat